基本信息
职称 主任医师
职务 规培基地教学主任
研究方向 肿瘤病理诊断及基础研究，分子病理
电子邮件 hudan@fjmu.edu.cn
个人简介
胡丹，女，福建省肿瘤医院病理科主任医师，副教授，福建省高层次C类人才。福建医科大学及福州大学硕士生导师。第四届中国杰出青年病理医师，吴秉铨病理专项奖学金获得者。主要社会任职：国际妇科病理学家协会会员(ISGyP)、中华医学会病理学分会女性生殖疾病学组委员、福建省抗癌协会肿瘤病理专业委员会常务委员、福建省抗癌协会肿瘤内分泌与生育力保护专业委员会常务委员。以第一作者/通讯作者发表SCI 30余篇，IF总100余分，系列研究入选2016 CSCO年度进展。主持省级课题4项，参与多项国家级及省级课题。获福建省自然科学论文二等奖，以主要完成人获福建医学科技一等奖、福建医学科技进步奖三等奖、福建省抗癌协会科技进步奖。主译专著二部。
主要科研项目
1.国家自然科学基金面上项目，拮抗Pin1/BRD4在抑制高糖诱导血管平滑肌细胞增殖中的作用及机制，2020-01-01至2023-12-31，55万元，参与，已结题
2.福建省科技创新联合资金项目，基于高通量测序胃癌IRNA谱的筛查验证及相关机制研究，2019.09-2022.09，15万元，主持，已结题
3.福建省科技创新联合资金攀登项目，Hsa-cicrRNA-0001017通过miR221-3p/
PRUNE1调控宫颈癌侵袭转移的分子机制研究，2023.9-2026.9,50万，在研，主持
4.福建省医学创新课题，Circ 0001017福建在宫颈癌中的表定及其靶向miR-221-3p相关生物学功能研究，2023.9-2026.9,15万，主持，在研
5.福建省自然科学基金课题，单细胞测序联合空间转录组学对宫颈鳞症PD-L1和HER2分子遗传学异质性的研究，2024.9-2027.9，15万，主持，在研
主要获奖经历
1.福建省自然科学论文二等奖（第1完成人）
2.2018年福建省抗癌协会科技进步奖三等奖(第3完成人)
3.2019年福建医学科技进步奖三等奖(第4完成人)
4.2024年福建省抗癌协会科技进步奖二等奖(第4完成人)
5.2024年福建省抗癌协会科技进步奖三等奖(第4完成人)
近5年发表的主要论文
1.Dan Hu, Zhaolei Cui,Wei Peng,Xiaojiang Wang,Yapeng Chen, Xiufeng Wu6.Apelin is associated with clinicopathological parameters and prognosis in breast cancer patients. Archives of Gynecology and Obstetrics,2022;306(4):1185-1195.
2.Jianjian Yu, Dan Hu, Laicheng Wang , Zongcheng Fan , Changsheng Xu , Yunchai Lin , Xin Chen , Jinxiu Lin,Feng Peng.Hyperglycemia induces gastric carcinoma proliferation and migration via the Pin1/BRD4 pathway.Cell Death Discovery,2022; 8:224
3.Xinran Zhang,Dan Hu, Xiangling Deng, Jinxiu Lin, Xiongwei Zheng, Feng Peng, Fanqiang Meng , Wenquan Niu.Prediction of presurgical metabolic syndrome for gastric cancer-specific mortality is more evident in smokers: The FIESTA study.Cancer Medicine. 2022;00:1–14.
4.Laicheng Wang, Dan Hub, Zongcheng Fana, Jianjian Yua, Shunpeng Zhanga, Yunchai Lina, Xin Chena, Xiandong Linc, Xiyao Yanb, Jinxiu Lina, Feng Penga。Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative gastric cancer patients: the FIESTA study.BMC Gastroenterology, 2022; 22:429
5.Dan Hu, Laicheng Wang, Xin Chen,Yunchai Lin, Shunpeng Zhang, Zongcheng Fan,3 and Feng Peng.Impact of PIWIL1 Single Nucleotide Polymorphisms on Gastric Cancer Risk in a Chinese Population.Genet Test Mol Biomarkers,2023;27(6):185-
192.
6.Ying Li, Youliang Weng, Zongwei Huang, Yuhui Pan , Sunqin Cai1 , Qin Ding , Zijie Wu , Xin Chen , Jun Lu1, Dan Hu and Sufang Qiu.Prognostic model on overall survival in elderly nasopharyngeal carcinoma patients: a recursive partitioning analysis identifying pretreatment risk stratification.Radiation Oncology ,2023, 18(1):104
7.Wei Liu, Yan-Mei Cui, Xiao-Jiang Wang, Xian-Dong Lin, Li-Bin Zhang, Jing-Cheng Liu, Qing-Hu Lyu, Wei Chen , Dan Hu.Lung adenocarcinoma metastatic to the ovary: aretrospective clinicopathological analysis of 17 cases andliterature review.Pathology,2024 ;56(7):942-950.
8.Jing Liu, Dan Hu, Yibin Lin, Xiaoxi Chen, Ruowei Yang , Li Li , Yanyan Zhan, Hua Bao, LeLe Zang, Mingxuan Zhu, Fei Zhu, Junrong Yan, Dongqin Zhu, Huiqi Zhang, Benhua Xu, Qin Xu.Early detection of uterine corpus endometrial carcinoma utilizing plasma cfDNA fragmentomics. BMC Medicine.2024,22(1):310.
9.Qin Ding , Mingzhu Liu , Yuhui Pan, Ziyi Wu , Jing Wang, Yi Li, Xiaoyong Liu, Jinghua Lai, Dan Hu, Sufang Qiu.Tumor-related IGF2BP1-derived molecular subtypes to predict prognosis and immune microenvironment in head and neck squamous cell carcinoma.Front Immunol. 15:1469435
10.延胡索酸水合酶缺失型子宫平滑肌瘤38例患者的多中心回顾性研究 闫熙瑶 ，林建龙，田瑞华，翁秀清，王丽，邹宗楷，李新华，林贤东，陈刚， 胡丹中华妇产科杂志 2022 年6 月第 57 卷第 6 期 435-461.通讯作者。
11.SMARCA4蛋白表达缺失性子宫内膜去分化癌/未分化癌的临床病理分析。刘伟， 师怡， 王晓江， 崔艳梅，何同梅， 柳景成，朱伟峰，徐沁， 胡丹。中华妇产科杂志 2024 年11 月第 59 卷第 11 期 856-863。
12.Xingming Ye, Jianfeng Zheng, Dan Hu, Li Liu, Fukun Chen , Xintong Cai1 , Yangmei Xu, Lifeng Li, Jie Lin, Qinying Liu,Yang Sun.Identification of increased dedifferentiation along the Prom1+ cancer cells in Müllerian adenosarcoma with sarcomatous Overgrowth.Br J Cancer. 2025;132(5):438-449.
13.Dan Hu, Xinran Zhang, Xiandong Lin, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Feng Peng, Wenquan Niu .Interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of 4330 Chinese patients with gastrointestinal tract cancerJ Cancer,2020 Jan 1;11(4):867-873.
14.Ying Li, Lishui Wu, Zongwei Huang, Sunqiu Cai , Siqi Xu , Jue Wang , Yuxin Yu , Jinghua Lai , Dan Hu, and Sufang Qiu1. Prognostic implications of EBER and EBV DNA combinations in nasopharyngeal carcinoma in endemic areas BMC Oral Health,2025,25:1361
15.Chenan Liu, Laicheng Wang , Mei Lin, Jing You, Xuan Zheng, Ailing Wang,Yunchai Lin , Feng Peng, Dan Hu.Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study.Front Cardiovasc Med, 2025 , 22:12:1415263.
16.Qin Xu, Zhengrong Deng, Jing Liu, Yanhong Zhuo, Fei Zhu, Lele Chang, Qin Liu, Yajuan Fu, Peiwei Li, Yunyun Liu, Songhua Huang, Li Li, Xingyun Xie, Ying Chen, Yingtao Lin, Lele Zang, Meifang Ke, Li Chen, Xiaoxia Huang, Cong Wang, Yanhong Wang, Yaxin Kang, Yuqin Wang, Mingxuan Zhu, Huiqi Zhang, Zhixin Wang, Peidong Zhang, Dan Hu,Huaiwu Lu, Yang Sun, Shengtao Zhou.Molecular and immune correlates of response to first-line de-escalated chemotherapy plus penpulimab and anlotinib in advanced cervical cancer.Cancer Discov, 2025, 26.
17.Xiaochuan Chen , Zhangying Jiang , Junping Pan , Wenqian Xu , Ying Li , Xin Chen , Yuhui Pan, Youliang Weng, Dan Hu, Sufang Qiu.Integrated multi-omics reveal lactate metabolism-related gene signatures and PYGL in predicting HNSCC prognosis and immunotherapy efficacy.BMC Cancer. 2025,24;25(1):773.
18.Xingming Ye, Jianfeng Zheng, Dan Hu, Li Liu, Fukun Chen, Xintong Cai, Yangmei Xu, Lifeng Li, Jie Lin, Qinying Liu, Yang Sun.Identification of increased dedifferentiation along the Prom1+ cancer cells in Müllerian adenosarcoma with sarcomatous overgrowthBr J Cancer,2025,132(5):438-4
19.Wenjuan Chen, Chenying Liu, Siyi Li, Xingyun Xie, Dan Hu, Yaobin Lin.ZC3H18 regulates alternative splicing and related genes in cervical cancer.Front Genet, 2025, 9:16:1621238.
20.Jing Liu, Yanwen Song, Qin Liu, Li Li, Junping Pan, Lan Luo , Shitao Zhu, Dongmei Wu, Dan Hu , Qin Xu.Prognostic significance of chemotherapy response score in predicting outcomes for high-grade serous ovarian carcinoma patients undergoing neoadjuvant chemotherapy.Transl Cancer Res, 2025,30;14(4):
2319-2330.
21. Huaiwu Lu, Yuqin Wang, Lele Chang, Jing Liu, Mingxuan Zhu, Yanhong Wang, Dongdong Xu, Dongdong Ye, Zhongqiu Lin , Shaohua Xie, Bingbing Zhao, Dan Hu, Qin Xu.Treatment patterns and prognosis of patients with locally advanced vulvar cancer: a retrospective cohort study of the SEER database and a Chinese multicenter registry.Gynecol Oncol. 2025 ,203:171-181.
22.Wei Liu, Xiaojiang Wang, Yanmei Cui, Keyi Song, Weiqing Lin, Xi Lei, Xiuqin Weng, Wucheng Shen, Jingcheng Liu , Libin Zhang , Wenxiu Miao, Juncheng Ye, Tongmei He , Qin Xu , Dan Hu .HER2 expression in cervical squamous cell carcinoma: high prevalence of HER2-low/ultralow and spatiotemporal heterogeneity across tumor evolution.NPJ Precis Oncol,2025,28;9(1):410.
23.Wei Liu, Yan-Mei Cui, Zheng-Jin Liu, Xiao-Jiang Wang, Li-Bin Zhang , Mei-Fang Zhang, Wen-Xiu Miu, Xi-Yao Yan, Hui-Lin Zhang, Shu-Qi Yang, Wen Li , Jun-Cheng Ye , Tong-Mei He, Yi Shi, Dan Hu .Epstein-Barr virus-associated intrahepatic cholangiocarcinoma: a diverse morphological spectrum that correlates with patient prognosis.Pathology, 2025,57(7):890-900.
