基本信息
职称：副教授
研究方向：生物化学分析及检测
电子邮件：bingqianlin@fzu.edu.cn
办公地点：福州大学旗山校区国家大学科技园7号楼419-1
个人简介
主要基于生物化学分析的液体活检及体外诊断技术研究。在Nature Communications、Angewandte Chemie International Edition、Chemical Science等期刊以第一/通讯作者（含共同）发表论文11篇，累计发表SCI论文30余篇。主持并参与多项国家级自然科学基金项目。
工作经历
2025年-至今 福州大学医工交叉研究院，副教授
2022年-2025年 武汉大学，化学与分子科学学院，博士后（合作导师：周翔院士）
2021年-2022年 武汉大学中南医院，医学科学研究中心，助理研究员
教育背景
2017年-2021年 厦门大学，化学化工学院，博士（导师：杨朝勇教授、朱志教授）
2013年-2016年 厦门大学，化学化工学院，硕士（导师：杨朝勇教授）
2009年-2013年 中国地质大学（武汉），材料与化学学院，学士
主要科研项目
1.福州大学，科研启动项目 XRC-25146，主持
2. 福州大学，福州大学福建省高校测试中心开放基金 2026T075，主持
3. 国家自然科学基金委员会，青年科学基金项目 22307101，主持，已结题
4. 中国博士后科学基金，面上项目，2022M712457，主持，已结题
5. 国家自然科学基金委员会, 国家重大科研仪器研制项目, 21927806, 参与，已结题
发表的主要论文 (†共一，*通讯)
1. Lin, B. †; Jiao, Z. †; Dong, S. †; Yan, W.; Jiang, J.; Du, Y.; Weng, X. *; Wang, H. *; Hu Z. *; Liu, Y. *, Zhou X. *; Whole-genome methylation sequencing reveals the role of extracellular vesicles in intercellular communication. Nature Communications 2025, 16 (1), 8084.
2. Lin, B. *; Jiang, J.; Zhou, X., Recent advances in design strategies of aptamer-based liquid biopsy. Journal of Polymer Science 2024, 62 (13), 2848-2870.
3. Lin, B. *; Xiao, F.; Jiang, J.; Zhao, Z.; Zhou, X., Engineered aptamers for molecular imaging. Chemical Science 2023, 14 (48), 14039-14061.
4. Lin, B. *; Jiang, J.; Jia, J.; Zhou, X. *, Recent Advances in Exosomal miRNA Biosensing for Liquid Biopsy. Molecules 2022, 27 (21), 7145.
5. Lin, B.; Tian, T.; Lu, Y.; Liu, D.; Huang, M.; Zhu, L.; Zhu, Z.; Song, Y. *; Yang, C. *, Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR. Angewandte Chemie International Edition 2021, 60 (14), 7582-7586.
6. Lin, B.; Lei, Y.; Wang, J.; Zhu, L.; Wu, Y.; Zhang, H.; Wu, L.; Zhang, P. *; Yang, C. *, Microfluidic-Based Exosome Analysis for Liquid Biopsy. Small Methods 2021, 5 (3), 2001131.
7. Lin, B. †; An, Y. †; Meng, L.; Zhang, H.; Song, J.; Zhu, Z.; Liu, W. *; Song, Y. *; Yang, C. *, Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs. Chemical Communications 2019, 55 (81), 12223-12226.
8. Lin, B.; Guan, Z.; Song, Y.; Song, E.; Lu, Z.; Liu, D.; An, Y.; Zhu, Z.; Zhou, L.; Yang, C. *, Lateral flow assay with pressure meter readout for rapid point-of-care detection of disease-associated protein. Lab on a Chip 2018, 18 (6), 965-970.
9. Lin, B.; Liu, D.; Yan, J.; Qiao, Z.; Zhong, Y.; Yan, J.; Zhu, Z.; Ji, T.; Yang, C. J. *, Enzyme-encapsulated liposome-linked immunosorbent assay enabling sensitive personal glucose meter readout for portable detection of disease biomarkers. ACS applied materials interfaces 2016, 8 (11), 6890-6897.
10. Lu, Y. †; Lin, B. †; Liu, W.; Zhang, J.; Zhu, L.; Yang, C.; Song, Y. *, Isolation of PD-L1 Extracellular Vesicle Subpopulations Using DNA Computation Mediated Microfluidic Tandem Separation. Small Methods 2023, 7 (9), 2300516.
11. Liu, D. †; Lin, B. †; Shao, W.; Zhu, Z.; Ji, T. *; Yang, C. *, In vitro and in vivo studies on the transport of PEGylated silica nanoparticles across the blood-brain barrier. ACS applied materials interfaces 2014, 6 (3), 2131-2136.
12. Wu, Y.; Lin, B.; Lu, Y.; Li, L.; Deng, K.; Zhang, S.; Zhang, H.; Yang, C.; Zhu, Z. *, Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins. Angewandte Chemie International Edition 2023, 62 (15), e202218106.
13. Zhang, J.; Lin, B.; Wu, L.; Huang, M.; Li, X.; Zhang, H.; Song, J.; Wang, W.; Zhao, G. *; Song, Y. *; Yang, C. *, DNA Nanolithography Enables a Highly Ordered Recognition Interface in a Microfluidic Chip for the Efficient Capture and Release of Circulating Tumor Cells. Angewandte Chemie International Edition 2020, 59 (33), 14115-14119.
14. Huang, D.; Lin, B.; Song, Y.; Guan, Z.; Cheng, J.; Zhu, Z. *; Yang, C. *, Staining Traditional Colloidal Gold Test Strips with Pt Nanoshell Enables Quantitative Point-of-Care Testing with Simple and Portable Pressure Meter Readout. ACS Applied Materials & Interfaces 2019, 11 (2), 1800-1806.
15. Song, Y.; Lin, B.; Tian, T.; Xu, X.; Wang, W.; Ruan, Q.; Guo, J.; Zhu, Z.; Yang, C. *, Recent progress in microfluidics-based biosensing. Analytical chemistry 2018, 91 (1), 388-404.
16. Du, Y.; Tang, Y.; Lin, B.; Xue, X.; Wang, Y. *; Liu, Y. *, Bisulfite-free mapping of DNA cytosine modifications: challenges and perspectives. Science China Chemistry 2023, 66 (11), 3044-3053.
17. Zhang, H.; Wu, L.; Lin, B.; Wang, Y.; Bi, Y.; Wang, W.; Song, Y.; Yang, C. *, Recent progress on microfluidic technology-based circulating tumor cell analysis. SCIENTIA SINICA Chimica 2019, 49 (9), 1220-1236.
18. Sun, M.; Fang, X.; Lin, B.; Mo, J.; Wang, F.; Zhou, X.; Weng, X. *, Locus-specific detection of pseudouridine with CRISPR-Cas13a. Chemical Communications 2024, 60 (30), 4088-4091.
