基本信息

职称：主任医师

职务：病理科科室主任

研究方向 ：淋巴瘤病理诊断与分子机制研究；基于多光子光学成像与人工智能的胃肠道肿瘤精准诊疗

电子邮件：naichengang@126.com

个人简介

陈刚，男，福建省肿瘤医院门诊医技党总支部书记、主任医师、博士生导师。硕士毕业于福建医科大学。现任中华医学会病理学分会常务委员、中国医疗保健促进委员会病理学分会副主任委员、中国医疗器械行业协会病理专业委员会副主任委员、中国研究型医院学会病理学专委会副主任委员、中华医学会病理学分会病理技术学组组长、国家病理质控中心委员会委员兼技术质控组组长、中国抗癌协会肿瘤病理专业委员会淋巴瘤学组组长、中国医疗器械行业协会病理专业委员会淋巴瘤学组组长、福建省医学会病理学分会主任委员、福建省抗癌协会肿瘤病理专业委员会主任委员、《中华病理学杂志》、《白血病•淋巴瘤》、《实用癌症杂志》编委，2020年与2022年世界卫生组织第五版《WHO Classification Tumours of Soft Tissue and Bone》和《WHO Classification Tumours of Skin》编委等重要社会任职。先后在Modern pathology、Histopathology、Am J Surg Pathol、Cell Research、JAMA Surgery、Nature Communications、Cell Death & Disease、Cancer Immunology Research等SCI杂志发表文章70余篇，总分值逾180分。主持翻译淋巴造血系统专著《血液病理学》第一版和第二版。

主要科研项目

1、省级创新平台建设项目，福建省肿瘤精准诊断与免疫治疗工程研究中心，2021.9-2024.9，500万，在研。

2、福建省科技计划重大专项（2019YZ016006），基于人工智能的胃癌精准诊断与治疗技术研究，2019.7-2023.6，400万，在研。

3、中央引导地方科技发展专项-重大项目（2019L3018），福建省肿瘤精准医疗产业技术创新研究院建设，2019.2-2022.3，120万，已结题。

4、省卫生厅中青年骨干人才培养资助计划（2013-ZQN-ZD-7），间变性大细胞淋巴瘤遗传学不平衡性的临床病理研究，2014.1-2017.1，20万，已结题。

5、福建省科技创新联合资金项目（2019Y9039），EZH2蛋白在系统性间变性大细胞淋巴瘤过表达机制及其生物学功能研究，2020.9-2023.8，15万，在研。

获奖经历

1、2021年，福建省科学技术进步奖三等奖，《胃肠肿瘤光子诊断关键技术创新与应用》，排名第3

2、2021年，福建省抗癌协会科技进步奖二等奖，《c-myc在恶性淋巴瘤中的诊断及预后应用》，排名第1

3、2018年，福建省科学技术进步奖三等奖，《乳腺癌精准诊断和治疗的研究与临床应用研究》，排名第2

4、2017年，福建医学科技奖（恒瑞杯）一等奖，《胃肠道恶性肿瘤易感及预后分子标志物的研究》，排名第5

5、2014年，第十一届福建省自然科学优秀学术论文二等奖，排名第1

近五年发表的主要论文

(1)Dexin Chen , Meiting Fu, Liangjie Chi, Liyan Lin, Jiaxin Cheng,Weisong Xue, Chenyan Long ,Wei Jiang, Xiaoyu Dong, Jian Sui, Dajia Lin,Jianping Lu, Shuangmu Zhuo* , Side Liu *, Guoxin Li *,Gang Chen* , Jun Yan*; Prognostic and predictive value of a pathomics signature in gastric cancer. Nat Commun. 2022;13(1):6903.(1区，IF：17.694).

(2)Jian-chao Wang, Li-hua Zhong, Wei-qing Lin, Wen-fang Zhang, Yan-feng Xi, Yue-pingLiu,QiongZhu,WeiLiu,Wei-fengZhu,Yan-pingChen,GangChen*.JAK/STAT3 Signaling Activation Related to Distinct Clinicopathologic Features in Systemic ALK−Anaplastic Large Cell Lymphomas:New Insights into Their Heterogeneity. Am J Surg Pathol . 2023;47(1):55-64(1区，IF：6.298).

(3)Dexin Chen, Zhangyuanzhu Liu,Wenju Liu, Meiting Fu, Wei Jiang, Shuoyu Xu, Guangxing Wang , Feng Chen, Jianping Lu, Hao Chen, Xiaoyu Dong, Guoxin Li*,Gang Chen*, Shuangmu Zhuo*,Jun Yan*, Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram. Nat Commun. 2021;12(1):179.(1区，IF：17.694).

(4)Zhengbo Song* , Yueping Liu, Guoping Cheng, Lianpeng Chang, Zicheng Yu, Ming Chen*,Gang Chen*,Distinct mutational backgrounds and clonal architectures implicated prognostic discrepancies in small-cell carcinomas of the esophagus and lung. Cell Death and Disease .2021;12(5):472. (1区，IF：9.696).

(5)Zhengbo Song, Xiangbin Chen, Yi Shi, Rongfang Huang, Wenxian Wang, Kunshou Zhu, Shaofeng Lin, Minxian Wang, Geng Tian, Jialiang Yang*,Gang Chen*. Evaluating the Potential of T-Cell Receptor Repertoires in Predicting the Prognosis of Resectable Non-Small Cell Lung Cancers. Methods & Clinical Development. 2020;18:73-83. (2区，IF：6.698).

(6)Chen D#,Chen G#, Jiang W#, Fu M#, Liu W, Sui J, Xu S, Liu Z, Zheng X, Chi L, Lin D, Li K, Chen W, Zuo , Lu J, Chen J, Li G, Zhuo S*, Yan J*, Association of the collagen signature in the tumor microenvirnment with lymph node metastasis in early gastric cancer. JAMA SURG. 2019;154(3):e185249.（1区，IF：13.625）.

(7)Chen Y#,Chen G#, Li J#, Huang YY#, Li Y, Lin J, Chen LZ, Lu JP, Wang YQ, Wang CX, Pan LK, Xia XF, Yi X, Chen CB, Zheng XW, Guo ZQ*, Pan JJ*. Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer. JAMA Netw Open. 2019;2(9):e1911895.(1区，IF：5.032).

(8)Wang F# *, Liu DB# , Zhao Q# ,Chen G#, Liu XM, Wang YN, Su H, Qin YR, He YF, Zou QF, Liu YH, Lin YE, Liu ZX, Bei JX, Xu RH*, The genomic landscape of small cell carcinoma of the esophagus.Cell Research. 2018;28(7):771-774.(1区，IF：17.848).

(9) Guo L, Lin P, Xiong H, Tu S*,Chen G*, Molecular heterogeneity in diffuse large B-cell lymphoma and its implications in clinical diagnosis and treatment,Biochim Biophys Acta. 2018;1869(2):85-96. (1区，IF：6.887).

(10)Yan-ping Chen, Wen-wen Zhang, Ya-ting Qiu, Longfeng Ke, Hao Chen*,Gang Chen*.PRAME is a useful marker for the differential diagnosis of melanocytic tumours and histological mimics. HISTOPATHOLOGY. 2023;82(2):285-295.(2区，IF：7.778).

(11)Ling Li , Fangfang Chen, Jingcheng Liu, Weifeng Zhu,Liang Lin, Li Chen, Yi Shi , An Lin，Gang Chen*.Molecular classification grade 3 endometrial endometrioid carcinoma using a next-generation sequencing-based gene panel.Front Oncol. 2022;12:935694.(3区，IF：5.738).

(12)Ziwei Hu,Yanglin Den,Junlin Lan,Tao Wang,Zixin Han,Yuxiu Huang,Hejun Zhang,Jianchao Wang,Musheng Cheng,Haiyan Jiang,Ren-Guey Lee, Ming Du,Tong Tong,Qinquan Gao*,Gang Chen*.A multi-task deep learning framework for perineural invasion recognition ingastric cancer whole slide images.Biomedical Signal Processing and Control.2022,79: 104261.(2区，IF：5.076).

(13) Jing Lin, Yu Chen, Wei-feng Tang, Chao Liu, Sheng Zhang, Zeng-qing Guo,Gang Chen*and Xiong-wei Zheng*. PPARG rs3856806 C>T Polymorphism Increased the Risk of Colorectal Cancer: A Case-Control Study in Eastern Chinese Han Population.Front Oncol. 2019;9:63.(3区，IF：4.848).

(14)Jing Lin, Yu Chen, Wei-feng Tang, Chao Liu, Sheng Zhang, Zeng-qing Guo,Gang Chen*,Xiong-wei Zheng*,PPARG rs3856806 C>T Polymorphism Increased the Risk of Colorectal Cancer: A Case-Control Study in Eastern Chinese Han Population.Front Oncol. 2019;9:63.(3区，IF：4.848).

(15)Song Z*, Wang H, Yu Z, Lu P, Xu C,Chen G*, De Novo MET Amplification in Chinese Patients With Non Small-Cell Lung Cancer and Treatment Efficacy With Crizotinib:A Multicenter Retrospective Study. CLIN LUNG CANCER. 2019;20(2):e171-e176.(2区，IF：3.55).

(16)Xu CW, Wang WX, Chen YP, Chen Y, Liu W, Zhong LH, Chen FF, Zhuang W, Song ZB, Chen XH, Huang YJ, Guan YF, Yi X, Lv TF, Zhu WF, Lu JP, Wang XJ, Shi Y, Lin XD,Chen G*, Song Y*, Simultaneous VENTANA IHC and RT-PCR testing of ALK status in Chinese non-small cell lung cancer patients and response to crizotinib. Journal of Translational Medicine, 2018;16(1):93.(2区，IF：4.098).

(17)Qiong Zhu , Jianchao Wang , Wenfang Zhang , Weifeng Zhu , Zaizeng Wu , Yanping Chen ,Musheng Chen , Limei Zheng , Jianqing Tang , Sheng Zhang , Di Wang , Xingfu Wang* ,Gang Chen*.Whole-Genome/Exome Sequencing Uncovers Mutations and Copy Number Variations in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System.Front Genet. 2022;13:878618.(3区，IF：4.772).

(18)Tao Wang, Junlin Lan, Zixin Han,Ziwei Hu,Yuxiu Huang, Yanglin Deng,Hejun Zhang, Jianchao Wang, Musheng Chen, Haiyan Jiang, Ren-Guey Lee, Qinquan Gao,Ming Du, Tong Tong*,andGang Chen*.O-Net: A Novel Framework With Deep Fusion of CNN and Transformer for Simultaneous Segmentation and Classification.Frontiers in Neuroscience.2022,16.(2区，IF：5.152).

(19)Zixin Han, Junlin Lan, Tao Wang, Ziwei Hu, Yuxiu Huang, Yanglin Deng, Hejun Zhang, Jianchao Wang, Musheng Chen, Haiyan Jiang, Ren-Guey Lee, Qinquan Gao, Ming Du, Tong Tong*, andGang Chen*.A Deep Learning Quantification Algorithm for HER2 Scoring of Gastric Cancer.Frontiers in Neuroscience .2022,16.(2区，IF：5.152).

(20)Jianchao Wang, Wangyang Tang , Wenfang Zhang, Jiesong Wang, Fangfang Chen, Lihua Zhong , Yanping Chen* ,Gang Chen*,Clinicopathological characterization of follicular helper T-cell-derived peripheral T-cell lymphoma involving Waldeyer’s ring. VIRCHOWS ARCH. 2021;479(2):355-363.(3区，IF：4.548).

(21)JUNLIN LAN, SHAOJIN CAI, YUYANG XUE, QINQUAN GAO, MIN DU, HEJUN ZHANG, ZHIDA WU, YANGLIN DENG, YUXIU HUANG, TONG TONG*, ANDGANG CHEN*.Unpaired Stain Style Transfer Using Invertible Neural Networks Based on Channel Attention And Long-range Residual.IEEEAccess.2021,9: 11282-11295.(3区，IF：3.476).

(22)Yi Shi, Xiaofei Mo, Simei Hong, Tianbao Li, Baozhen Chen,Gang Chen*.Studying the role and molecular 1 mechanisms of MAP4K3 in sorafenib resistance of hepatocellular carcinoma.BIOMED RES INT. 2020;2020:4965670.(4区，IF：3.411).

(23)Yan-ping Chen，Long-feng Ke,Jian-ping Lu，Jian-chao Wang，Wei-feng Zhu，Fang-fang Chen，Shao-feng Lin，Chun-wei Xu，Mei-juan Wu *，Gang Chen*.Prevalence And Clinical Significance Of Oncogenic CD79B And MYD88 Mutations In Primary Testicular Diffuse Large B-Cell Lymphoma:A Retrospective Study In China.Onco Targets Ther. 2019;12:10165-10175.(3区，IF：3.337).

(24)Y. Chen, B. Chen, W. Zhu, T. He , J. Lu , C. Xu ,G. Chen*. The clinical significance of c-MYC expression, rearrangement, and copy number gain in extranodal NK/T-cell lymphoma:A retrospective study in China.Experimental and Molecular Pathology (3区，IF：2.566).

(25) Chen Y, Tang W, Liu C, Lin J, Wang Y, Zhang S,Chen G*, Zheng X*.miRNA-146a rs2910164 C>G polymorphism increased the risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 participants, Cancer Manag Res. 2018;10:1657-1664(4区，IF：2.243).