基本信息
职称 助理研究员
职务 无
研究方向 肿瘤与微生物多组学联合研究
电子邮件 dangyuan830307@hotmail.com
个人简介
党源，女，博士,助理研究员。硕士与博士毕业于吉林大学。在加拿大蒙特利尔大学兽医系做访问学者。主要从事肿瘤多组学联合分析、肿瘤个体化治疗研究、肝癌早筛队列研究、胆管癌代谢组学研究。在国内外重要学术期刊和会议上发表论文30多篇。
主要科研项目
主持课题：
1.科技创新联合资金项目, 2021Y9197,肠道菌群介导的胆汁酸代谢通过免疫微环境调控肝内胆管癌发生发展的机制研究, 2022-10至2025-10, 15万元,在研,主持。
2.军队实验动物专项科研项目，SYDW〔2017〕13，间充质干细胞及其外泌体修复海水浸泡创面的疗效与机制，2019/01-2021/12，20万元，结题，主持。
3.福建医科大学启航基金一般项目，2017XQ1196，LINC01089对人胶质瘤细胞增殖的影响，2018/01-2020/12，5万元，结题，主持。
4.福建省自然基金面上项目，2018J01339，LncRNA RP11-151D14.1调节胃腺癌增殖转移，2018/04-2021/4，8万元，结题，主持。
5.南京军区福州总医院杰出青年培育专项，2017Q03，lncRNA AFAP1-AS1/miR-205-5p/PTEN调控网络在胃癌发展中机制的研究，2018/01-2020/12，10万元，结题，主持。
获奖经历
1．2020年，福建省科学技术进步奖三等奖（第二），胃癌基因诊断与综合治疗方法改进
近五年发表的主要论文
1.Yuan Dang, Qianhui Xu, Xiaofang Liu, Lie Wang, Chen Lin. Clinical and functional characterisation of the SMAD4 germline variant c.1035C>A in a family withjuvenile polyposis syndrome by whole‑exome sequencing. Med Mol Morphol. 2022 Jul 18.
2. Lele Tang#,Yuan Dang#, Yu Wang, Yunlong Zhang, Tianshuo Hu, Cuicui Ding, Hui Wu, Yonghao Ni, Lihui Chen, Liulian Huang*, Min Zhang*. Rapid fabrication of bionic pyrogallol-based self-adhesive hydrogel with mechanically tunable, self-healing, antibacterial, wound healing, and hemostatic properties. Biomaterials Advances. 2022 May; 136: 212765.
3.Yuan Dang, Xiaojuan Ouyang, Wenjun Ren, Lie Wang, Qiaojia Huang. LncRNA AFAP1-AS1 Modulates the Proliferation and Invasion of Gastric Cancer Cells by Regulating AFAP1 via miR-205-5p. Cancer Management and Research 2021:13 5163–5175.
4. Feng Deng#,Yuan Dang#, Lele Tang, Tianshuo Hu, Cuicui Ding, Xiaoqing Hu, Hui Wu, Lihui Chen, Liulian Huang, Yonghao Ni, Min Zhang. Tendon-inspired fibers from liquid crystalline collagen as the pre-oriented bioink. International Journal of Biological Macromolecules. 2021 Aug 31; 185:739-749.
5. Shen B, Xu Q, Lin C, Lin C*,Dang Y*. Angioleiomyomatous hamartoma of lymph nodes: A case report. Asian J Surg. 2020 Nov 9: S1015-9584(20)30333-X.
6．Lin N, Xu Q, Wang B,Dang Y*, Lin C*. Male HER-2 positive metastatic breast cancer: A case report. Asian J Surg. 2020 Oct 16: S1015-9584(20)30284-0.
7．Dang Y, Liu F, Zhao Y. P-Gp and TOPO II Expression and Their Clinical Significance in Colon Cancer. Ann Clin Lab Sci. 2020 Sep;50(5):584-590.
8．Xu Q, Liu W, Lin C,Dang Y*, Lin C*. Transverse colon cancer with obstruction in a patient with situs inversus totalis: A case report and review of literature. Asian J Surg. 2020 Sep 26:S1015-9584(20)30277-3.
9. Cuicui Ding, Mengdie Tian, Ren Feng,Yuan Dang*,Min Zhang*. Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan. ACS Biomater. Sci. Eng. 2020, 6, 3855−3867.
10．Cuicui Ding, Qili Yang, Mengdie Tian, Chenchen Guo, Feng Deng,Yuan Dang*, Min Zhang*. Novel collagen‐based hydrogels with injectable, self‐healing, wound‐healing properties via a dynamic crosslinking interaction. Polymer International Early. 20 April 2020.
11．Dang Y, Lin L, Ouyang X, Zhang F, Chen S, Wang B, Zhang Z, Chen S, Deng L, Wang W, Wang L, Xiao C, Qi Y. LncRNA Expression Profiling in AdvancedResected Gastric Adenocarcinoma Tissues. Clin Lab. 2019 Dec 1;65(12).
12．Pan Y, Lu F, Fei Q, Yu X, Xiong P, Yu X,Dang Y, Hou Z, Lin W, Lin X, Zhang Z, Pan M, Huang H. Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer. J Hematol Oncol. 2019 Nov 27;12(1):124.
13. Wang Y, Wang G, Tan X, Ke K, Zhao B, Cheng N,Dang Y, Liao N, Wang F, Zheng X, Li Q, Liu X, Liu J. MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53. Oncogenesis. 2019 Nov 15;8(12):67.
14. Gao J, Ren W, Xiao C, Wang L, Huang Q, Zhang Z,Dang Y, Weng P, Wang H, Fang X, Zhuang M, Lin L, Chen S. Involvement of SLC39A6 in gastric adenocarcinoma and correlation of the SLC39A6 polymorphism rs1050631 with clinical outcomes after resection. BMC Cancer. 2019 Nov 8;19(1):1069.
15. Mu SW#,Dang Y#, Fan YC, Zhang H, Zhang JH, Wang W, Wang SS*, Gu JJ*. Effect of HMGB1 and RAGE on brain injury and the protective mechanism of glycyrrhizin in intracranial‑sinus occlusion followed by mechanical thrombectomy recanalization. Int J Mol Med. 2019 Jun 20.
16. Zhao B, Wang Y, Tan X, Zheng X, Wang F, Ke K, Zhang C, Liao N,Dang Y, Shi Y, Zheng Y, Gao Y, Li Q, Liu X*, Liu J*. An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy. Theranostics. 2019 Mar 6; 9(7):1837-1850.
17. Sun B,Dang Y, Zhang F, Li K, Ouyang X, Wang K, Huang Q*. Long non-coding RNA RP1-163G9.1 is downregulated in gastric adenocarcinoma and is associated with a poor prognosis. Oncol Rep. 2019 Jun;41(6):3575-3585.
18. Gu J#, Xu F#,Dang Y*, Bu X*. Long Non-Coding RNA 001089 is a Prognostic Marker and Inhibits Glioma Cells Proliferation and Invasion. Clin Lab. 2019 Mar 1;65.
19.Dang Y, Wei X, Xue L, Wen F, Gu J, Zheng H. Long Non-Coding RNA in Glioma: Target miRNA and Signaling Pathways. Clin Lab. 2018 Jun 1;64(6):887-894.
20.Ouyang Xiaojuan#,Dang Yuan#, Zhang Fan, Huang Qiaojia*. Low Serum Albumin Correlates with Poor Survival in Gastric Cancer Patients. Clin Lab. 2018;64: 239-245.
21.Wang Zhihua, Wang Kai,Dang Yuan,Ouyang Xiaojuan, Zhang Fan, Wang Wenyuan, Wang Lie*, Huang Qiaojia*. Evaluation of the expression and clinical valu e of lncRNA AC010761.9 in human gastric adenocarcinoma. World J Surg Oncol. 2018 Mar 2;16(1):40.
