基本信息

职称：教授、主任医师

职务：科主任

研究方向：肿瘤免疫、肿瘤细胞信号通路

电子邮件：zjyunbin@189.cn

个人简介

叶韵斌，女，博士，教授、主任医师。本科毕业于厦门大学，硕士与博士毕业于福建医科大学，留学法国。1989年起至今任职于福建省肿瘤医院，目前为肿瘤免疫学研究室暨肿瘤内科研究室科主任，专业技术三级，福建省高层次人才C类。兼任福州大学化学学院硕士研究生导师，福建省肿瘤转化医学重点实验室主任。曾在法国巴黎Cochin细胞分子遗传学研究所做博士后研究员、美国MD Anderson癌症研究中心细胞和分子肿瘤学系做访问学者。长期从事肿瘤免疫的基础研究和临床应用，以及肿瘤细胞信号通路与抗肿瘤靶点的研究。兼任中国肿瘤生物治疗杂志、肿瘤研究与临床、中华细胞与干细胞杂志编委，中国免疫学杂志特约审稿人，国外多家SCI期刊审稿人。在国际SCI及国家级和省级刊物上发表学术论文100多篇。

主要科研项目

1.基于新抗原mRNA纳米疫苗诱导的CTL抗肝癌作用研究，福建省科技厅引导性项目，2021.8-2024.5，主持

2.靶向肿瘤新抗原的TCR-T技术的研发及其在肝癌治疗中的应用，福建省科技创新联合资金项目，2019.9-2023.9，主持

3.基于胃癌特异性抗原的个体化过继细胞免疫治疗的研发，福建省科技厅对外合作项目，2018.4-2021.3，主持

4.肿瘤类器官与个体化/精准治疗研究，福建省肿瘤医院院内资助第三层次人才培养项目，2022.3-2026.3，主持

获奖经历

1. 2020年，第十四届福建省自然科学优秀学术论文（通讯作者）

2. 2019年，中国抗癌协会肿瘤标志专业委员会“突出贡献奖”

3. 2018年，福建省抗癌协会科技进步奖三等奖（第一）

近五年发表的主要论文

1. Zhifeng Zhou, Jieyu Li, Jingwen Hong, Shuping Chen, Mingshui Chen, Ling Wang, Wansong Lin,Yunbin Ye. Interleukin-15 and chemokine ligand 19 enhance cytotoxic effects of chimeric antigen receptor T cells using zebrafish xenograft model of gastric cancer. Front Immunol. 2022 Dec 23;13:1002361.

2. Jingwen Hong, Guoxiang Guo, Suxin Wu, Shengzhe Lin, Zhifeng Zhou, Shuping Chen, Chunmei Ye, Jieyu Li, Wansong Lin,Yunbin Ye. Altered MUC1 epitope-specific CTLs: A potential target for immunotherapy of pancreatic cancer. J Leukoc Biol. 2022 Dec;112(6):1577-1590.

3.Fang Liu, Shuping Chen, Yue Yu, Chuanzhong Huang, Huijing Chen, Ling Wang, Wanping Zhang, Junxin Wu,Yunbin Ye. Inhibitor of DNA binding 2 knockdown inhibits the growth and liver metastasis of colorectal cancer. Gene. 2022 Apr 20;819:146240.

4. Wansong Lin, Jie Lin, Jieyu Li, Ying Lin, Shuping Chen, Yijuan Wu, Lingfeng Chen, Hui Cheng, Lin Liu, Xiaoyan Chen,Yunbin Ye. Kindlin-2-miR-1258-TCF4 feedback loop promotes hepatocellular carcinoma invasion and metastasis. J Gastroenterol. 2022 May;57(5):372-386.

5. Cheng Lin, Meifang Li, Na Lin, Jingfeng Zong, Jianji Pan,Yunbin Ye. RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma. BMC Cancer, 2022 May 15;22(1):549.

6. Huahui Yu, Jieyu Li, Yuan Yuan, Yu Chen, Jingwen Hong, Chunmei Ye, Wansong Lin, Huijing Chen, Zengqing Guo, Bo Li,Yunbin Ye. Residue substitution enhances the immunogenicity of neoepitopes from gastric cancers. Cancer Biol Med. 2021 Nov 15;18(4):1053–65.

7. Hui-Jing Chen, Yue Yu, Yan-Xia Sun, Chuan-Zhong Huang, Jie-Yu Li, Fang Liu, Guo-Xiang Guo,Yun-Bin Ye. Id4 Suppresses the Growth and Invasion of Colorectal Cancer HCT116 Cells through CK18-Related Inhibition of AKT and EMT Signaling. J Oncol, 2021 Apr 14;2021:6660486.

8. Huahui Yu, Chunmei Ye, Jieyu Li, Chunli Pan, Wansong Lin, Huijing Chen, Zhifeng Zhou,Yunbin Ye. An altered HLA-A0201-restricted MUC1 epitope that could induce more efficient anti-tumor effects against gastric cancer. Exp Cell Res, 2020 May 1;390(1):111953.

9. Tianzhu Lu, Yiping Chen, Jieyu Li, Qiaojuan Guo, Wansong Lin, Yuhong Zheng, Ying Su, Jingfeng Zong, Shaojun Lin,Yunbin Ye, Jianji Pan. High Soluble Programmed Death-Ligand 1 Predicts Poor Prognosis in Patients withNasopharyngeal Carcinoma. Onco Targets Ther, 2020 Feb 26;13:1757-1765.

10. Jieyu Li, Wansong Lin, Huijing Chen, Zhiping Xu,Yunbin Ye, Mingshui Chen. Dual-target IL-12-containing nanoparticles enhance T cell functions for cancer immunotherapy. Cell Immunol, 2020;349:104042. doi:10.1016/j.cellimm.2020 Mar;349:104042.

11. Zhi-feng Zhou, Zhi Wei, Jin-Chan Yao, Shuo-yan Liu, Feng Wang, Zhen Wang, Xiao-feng Chen, Hui Lin,Yunbin Ye, Qing-feng Zheng. CircRNA_102179 promotes the proliferation, migration and invasion in nonsmall cell lung cancer cells by regulating miR-330-5p/HMGB3 axis. Pathol Res Pract, 2020 Nov;216(11):153144.

12. Yuan-Ji Xu, Rui Zhou, Jing-Feng Zong⁠, Wan-Song Lin, Shuang Tong, Qiao-Juan Guo, Cheng Lin, Shao-Jun Lin, Yi-Xin Chen, Mei-Ru Chen, Hong-Lin Chen,Yun-Bin Ye, Jian-Ji Pan. Epstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway. Cancer Lett, 2019 Apr 10;447:33-40.

13. Zhi-Feng Zhou, Feng Peng, Jie-Yu Li,Yun-bin Ye. Intratumoral IL-12 Gene Therapy Inhibits Tumor Growth In A HCC-Hu-PBL-NOD/SCID Murine Model. OncoTargets and Therapy, 2019, 20;12:7773-7784.

14. Yanxia Sun, Xiaolan Lai, Yue Yu, Jieyu Li , Lei Cao, Wansong Lin, Chuanzhong Huang, Jinrong Liao, Wei Chen, Chao Li, Chunkang Yang, Mingang Ying, Qiang Chen,Yunbin Ye. Inhibitor of DNA binding 1 (Id1) mediates stemness of colorectal cancer cells through the Id1-c-Myc-PLAC8 axis via the Wnt/β-catenin and Shh signaling pathways. Cancer Manag Res, 2019 Jul 23;11:6855-6869.

15. Chuan-zhong Huang, Ai-ming Huang, Jing-feng Liu, Bin Wang, Ke-can Lin,Yun-bin Ye. Somatostatin octapeptide inhibits cell invasion and metastasis in hepatocellular carcinoma through PEBP1. Cell Physiol Biochem, 2018, 47(6):2340-2349.

16. Jieyu Li, Shenglan Huang, Zhifeng Zhou, Wansong Lin, Shuping Chen, Mingshui Chen,Yunbin Ye. Exosomes derived from rAAV/AFP-transfected dendritic cells elicit specific T cell-mediated immune responses against hepatocellular carcinoma. Cancer Manag Res, 2018,10:4945-4957.