基本信息

职称：教授、博导，主任医师，专技二级

职务：福建省肿瘤医院党委书记，福建省肝胆医学中心主任

研究方向：肝胆外科、医疗大数据

电子邮件：drjingfeng@126.com

个人简介

刘景丰，男，博士。百千万人才工程国家级人选、国务院政府特殊津贴专家、国家卫生计生突出贡献中青年专家、全国卫生计生系统先进工作者、福建省劳动模范、福建省先进工作者、福建省科技创新领军人才、福建省优秀人才。

从事普外科、肝胆外科工作，建立和完善以肝肿瘤为主要对象的肝脏外科技术体系，对肝胆疾病的外科诊疗有较多积累。福建省肝胆胰临床研究中心主任、东南肝胆健康大数据研究所所长、福建省早筛早诊前沿技术重点实验室主任。兼任国际肝胆胰协会、亚太肝胆胰协会委员，国际肝胆胰协会中国分会共同主席，中华医学会肝病学分会、临床药学分会、数字医学分会常委，中国抗癌协会胆道肿瘤专委会、肿瘤代谢专委会、肿瘤肝脏病学专委会常委。福建省肝胆疾病和器官移植技术带头人，福建省医学会副会长，福建省预防医学会副会长，福建省抗癌协会名誉会长。

完成国家及省部级科研项目20多项，获国家科技进步二等奖1项（联合申报），省科技进步一等奖2项（第一完成人）、二等奖3项（其中第一完成人1项、第二完成人2项），国家发明专利45项，SCI论文累计影响因子751，主编和参编专著9部。

主要科研项目

1、肿瘤微环境H202出发的信号循环放大程序化控释纳米体系用于肿瘤协同治疗的研究，国家自然科学基金面上项目，2019.01~2022.12，主持

2、近红外光时序控释的基因-药物共输送纳米体系用于靶向治疗肝癌的研究，国家自然科学基金面上项目，2017.01~2022.12，主持

3、肿瘤微环境特异响应的诊疗纳米探针构建及其在肝癌诊疗中的应用研究，福建省科技创新联合资金项目，2019.09~2022.09，主持

获奖经历

1、2021年度福建省科学技术进步奖一等奖（第一完成人）

2、2018年度福建省科学技术进步奖一等奖（第一完成人）

3、2014年度国家科学技术进步奖二等奖（联合申报）

近五年发表的主要论文

[1] Aixian Zheng, Yanlin Du, Yiru Wang, Youshi Zheng, Zhaoyu Ning, Ming Wu, Cuilin Zhang, Da Zhang, Jingfeng Liu, Xiaolong Liu.CD16/PD-L1 bi-specific aptamer for cancer immunotherapy through recruiting NK cells and acting as immunocheckpoint blockade[J]. 2022 Jan 19;27:998-1009

[2] Jianxing Zeng, Jinhua Zeng, Kongying Lin, Haitao Lin, Qionglan Wu, Pengfei Guo, Weiping Zhou, Jingfeng Liu.Development of a machine learning model to predict early recurrence for hepatocellular carcinoma after curative resection[J]. 2022 Apr;11(2):176-187.

[3] Feida Li, Xiaoyan Wang, Ming Wu, Jianhua Guan, Yuzhi Liang, Xiaolong Liu, Xinyi Lin, Jingfeng Liu.Biosynthetic cell membrane vesicles to enhance TRAIL-mediated apoptosis driven by photo-triggered oxidative stress[J]. 2022 Jun 28;10(13):3547-3558.

[4] Da Zhang,Ziguo Lin, Ming Wu, Zhixiong Cai, Youshi Zheng, Lei He,Zhenli Li,Jie Zhou,Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu, Huanghao Yang,Xiaolong Liu.Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity[J]. 2021 Mar; 8(6): 2003504.

[5] Peiyuan Wang, Lianli Peng, Jinyan Lin, Yang Li, Qiang Luo, Suhua Jiang, Haina Tian, Yun Zhang, Xiaolong Liu, Jingfeng Liu.Enzyme hybrid virus-like hollow mesoporous CuO adhesive hydrogel spray through glucose-activated cascade reaction to efficiently promote diabetic wound healing[J]. 2021, Volume 415,128901

[6] Lei Chen, Ghassan K. Abou-Alfa, Bo Zheng, Jing-Feng Liu,Jian Bai, Lu-Tao Du, Yun-Song Qian, Rong Fan, Xiao-Long Liu, Lin Wu, Jin-Lin Hou，Hong-Yang Wang，The PreCar Team.Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients[J]. 2021 May;31(5):589-592

[7] Bo Zheng , Xiao-Long Liu , Rong Fan , Jian Bai , Hao Wen , Lu-Tao Du , Guo-Qing Jiang , Chun-Ying Wang , Xiao-Tang Fan , Yi-Nong Ye , Yun-Song Qian , Ying-Chao Wang , Gao-Jing Liu , Guo-Hong Deng , Feng Shen , He-Ping Hu , Hui Wang , Qing-Zheng Zhang , Lan-Lan Ru , Jing Zhang , Yan-Hang Gao , Jie Xia , Hua-Dong Yan , Min-Feng Liang , Yan-Long Yu , Fu-Ming Sun , Yu-Jing Gao , Jian Sun , Chun-Xiu Zhong , Yin Wang , Fei Kong , Jin-Ming Chen , Dan Zheng , Yuan Yang , Chuan-Xin Wang , Lin Wu , Jin-Lin Hou , Jing-Feng Liu , Hong-Yang Wang , Lei Chen .The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients[J]. 2021 Jul 1;27(13):3772-3783

[8] Xiaoyan Wang, Ming Wu, Xiaolong Zhang, Feida Li, Yongyi Zeng, Xinyi Lin, Xiaolong Liu, Jingfeng Liu.Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy[J]. 2021 Jul 8;19(1):204

[9] Bixing Zhao, Kun Ke, Yingchao Wang, Fei Wang, Yingjun Shi, Xiaoyuan Zheng, Xiaoyu Yang, Xiaolong Liu, Jingfeng Liu.HIF-1α and HDAC1 mediated regulation of FAM99A-miR92a signaling contributes to hypoxia induced HCC metastasis[J]. 2020 Jul 7;5(1):118

[10] Yang Li, Jinyan Lin, Peiyuan Wang, Qiang Luo, Fukai Zhu, Yun Zhang, Zhenqing Hou, Xiaolong Liu, Jingfeng Liu.Tumor Microenvironment Cascade-Responsive Nanodrug with Self-Targeting Activation and ROS Regeneration for Synergistic Oxidation-Chemotherapy[J]. 2020 Sep 14;12(1):182

[11] Zhixiong Cai, Geng Chen, Yongyi Zeng, Xiuqing Dong, Zhenli Li, Yanbing Huang, Fuli Xin, Liman Qiu, Haipo Xu, Wei Zhang, Xiaoping Su, Xiaolong Liu, Jingfeng Liu.Comprehensive Liquid Profiling of Circulating Tumor DNA and Protein Biomarkers in Long-Term Follow-Up Patients with Hepatocellular Carcinoma[J]. 2019 Sep 1;25(17):5284-5294.

[12] Yang Li, Jinyan Lin, Peiyuan Wang, Qiang Luo, Huirong Lin, Yun Zhang, Zhenqing Hou, Jingfeng, Xiaolong Liu .Tumor Microenvironment Responsive Shape-Reversal Self-Targeting Virus-Inspired Nanodrug for Imaging-Guided Near-Infrared-II Photothermal Chemotherapy[J]. 2019 Nov 26;13(11):12912-12928

[13] Da Zhang, Youshi Zheng, Ziguo Lin, Shanyou Lan, Xiaolong Zhang, Aixian Zheng, Juan Li, Gang Liu, Huanghao Yang, Xiaolong Liu, Jingfeng Liu.Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as a Powerful Strategy for Enhancing Photothermal‐Immunotherapy Efficiency of Solid Tumors[J]. 2019 Oct;15(42):e1902636