基本信息
职称 主任医师
职务 福建省肿瘤医院临床技能培训中心副主任
研究方向 黑色素瘤、泌尿肿瘤、软组织肿瘤大数据、基础及临床研究
电子邮件 chenl05@fjzlhospital.com
个人简介
陈玲，女，主任医师，肿瘤学硕士，硕士生导师。本科及硕士毕业于福建医科大学。专业从事黑色素瘤、泌尿肿瘤、软组织肿瘤以及胃癌、结直肠癌、肝癌、食管癌、胆胰肿瘤等消化系统恶性肿瘤的化疗、分子靶向治疗、免疫治疗及综合治疗。兼任中国抗癌协会第二届多原发和不明原发肿瘤专业委员会委员、福建省抗癌协会第一届黑色素瘤专业委员会常委兼秘书、中国抗癌协会肿瘤靶向治疗专业委员会青年委员会委员、福建省免疫学会第一届肿瘤免疫与生物治疗专业委员会委员、福建省输血协会第二届肿瘤患者血液管理专业委员会委员。主持或参与省级和厅级科研项目10余项，荣获福建省抗癌协会科技进步奖三等奖1项，并参与八十余项国际及国家级新药临床试验，发表专业论文20余篇。
主要科研项目
1.黏膜黑色素瘤的“血管和免疫”微环境特征与联合疗法的初步探索，2020.11-2023.11, 主持，福建省自然科学基金面上项目
2.NF－κB的表达与西妥昔单抗治疗大肠癌疗效的相关性，2010.05-2013.09，福建省卫生厅青年科研课题，主持
获奖经历
1、2015年福建省肿瘤内科学术大会青年论文交流 三等奖
2、2018年福建省抗癌协会科技进步奖 三等奖
近五年发表的主要论文
1.Chen L,Lin J, Chen Y, Yu J, Wang X. Clinicopathologic features and prognosis of 71 patients with gastric cancer and disseminated intravascular coagulation. PeerJ. 2023 Nov 27;11: e16527. doi: 10.7717/peerj.16527.
2.陈玲,林晶,王鼎屹,陈平,陈誉.黏膜黑色素瘤患者的临床特征及预后影响因素分析[J].肿瘤研究与临床,2023,35(7):537-540.DOI:10.3760/cma.j.cn115355-20230116-00037.
3.陈玲,林晶,陈丽珠,陈誉,王晓杰,郭增清,余家密,郑静娴.胃癌根治术后早期复发转移的影响因素分析[J].肿瘤学杂志,2020,26(12):1052-1055.
4.Chen L, Lin J, Chen LZ, Chen Y, Wang XJ, Guo ZQ, Yu JM. Perineural Invasion and Postoperative Complications are Independent Predictors of Early Recurrence and Survival Following Curative Resection of Gastric Cancer. Cancer Manag Res. 2020 Aug 21; 12:7601-7610. doi: 10.2147/CMAR.S264582.
5.陈玲,林晶,王晓杰,陈誉,陈丽珠,郭增清,余家密,郑静娴.人类表皮生长因子受体2在胃癌根治术后复发患者中的表达及其意义[J].肿瘤研究与临床,2020(03):178-179-180-181.
6.Du Y, Dai J, Mao L, Wei X, Bai X,Chen L, Lin J, Chi Z, Cui C, Sheng X, Lian B, Tang B, Wang X, Yan X, Li S, Zhou L, Guo J, Chen Y, Si L. Phase Ib study of anlotinib in combination with anti-PD-L1 antibody (TQB2450) in patients with advanced acral melanoma. J Eur Acad Dermatol Venereol. 2024 Jan;38(1):93-101. doi: 10.1111/jdv.19467.
7.Lin Z, Xiao H, Liu J,Chen L, Zhang H, Huang Y, Chen Y, Lin J. Clinical features and prognosis of cardiac metastatic tumors. BMC Cancer. 2023 Dec 15;23(1):1235. doi: 10.1186/s12885-023-11733-1.
8.Zheng X, Lin J, Xiong J, Guan Y, Lan B, Li Y, Gao X, Fei Z,Chen L, Chen L, Chen L, Chen G, Guo Z, Yi X, Cao W, Ai X, Zhou C, Li X, Zhao J, Yan X, Yu Q, Si L, Chen Y, Chen C. SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy. BMC Cancer. 2023 Jul 21;23(1):686. doi: 10.1186/s12885-023-10920-4.
9.Lin J, Liu J, Hao SG, Lan B, Zheng XB, Xiong JN, Zhang YQ, Gao X, Chen CB,Chen L, Huang YF, Luo H, Yi YT, Yi X, Lu JP, Zheng XW, Chen G, Wang XF, Chen Y. AnEGFRL858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy. Front Immunol. 2022 Nov 23;13:1022598. doi: 10.3389/fimmu.2022.1022598.
10.Zheng X, Jiang K, Xiao W, Zeng D, Peng W, Bai J, Chen X, Li P, Zhang L, Zheng X, Miao Q, Wang H, Wu S, Xu Y, Xu H, Li C, Li L, Gao X, Zheng S, Li J, Wang D, Zhou Z, Xia X, Yang S, Li Y, Cui Z, Zhang Q,Chen L, Lin X, Lin G. CD8+T cell/cancer-associated fibroblast ratio stratifies prognostic and predictive responses to immunotherapy across multiple cancer types. Front Immunol. 2022 Nov 9;13:974265. doi: 10.3389/fimmu.2022.974265.
11.Mao L, Fang M, Chen Y, Wei X, Cao J, Lin J, Zhang P,Chen L, Cao X, Chen Y, Guo J, Si L. Atezolizumab plus Bevacizumab in Patients with Unresectable or Metastatic Mucosal Melanoma: A Multicenter, Open-Label, Single-Arm Phase II Study. Clin Cancer Res. 2022 Nov 1;28(21):4642-4648. doi: 10.1158/1078-0432.CCR-22-1528.
12.Guo Z, Yuan Y, Chen C, Lin J, Ma Q, Liu G, Gao Y, Huang Y,Chen L, Chen LZ, Huang YF, Wang H, Li B, Chen Y, Zhang X. Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer. NPJ Precis Oncol. 2022 Jun 3;6(1):34. doi: 10.1038/s41698-022-00279-3.
13.Wang X, Chen Y, Lan B, Wang Y, Lin W, Jiang X, Ye J, Shang B, Feng C, Liu J, Zhai J, Xu M, Li Q, Lin L, Hu M, Zheng F,Chen L, Shao C, Wang Y, Shi Y. Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells. Theranostics. 2022 Jan 31;12(5):2063-2079. doi: 10.7150/thno.69198.
14.郑静娴,王晓杰,余家密,詹周伟,陈誉,陈玲,林晶,陈丽珠,黄于芳,郭增清.血常规及乳酸脱氢酶与胃癌根治术后患者预后的相关性研究[J].徐州医科大学学报,2020,40(12):887-892.
15.Yu JM, Zhan ZW, Zhen JX, Wang XJ, Chen Y, Lin J,Chen L, Chen LZ, Huang YF, Guo ZQ. Clinical Characteristics and Prognostic Analysis of Patients With Signet Ring Cell Gastric Carcinoma. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820983812. doi: 10.1177/1533033820983812.
16.范芳,余炜,刘捷,陈玲,林榕波.真实世界中阿帕替尼血药浓度研究[J].临床合理用药杂志,2020,13(05):117-118.
17.范芳,余炜,刘捷,陈玲,林榕波.反相高效液相色谱法测定血清中阿帕替尼的浓度[J].海峡药学,2020,32(01):52-54.
18.陈丽珠,陈誉,林晶,郑静娴,陈玲,郭增清.紫杉醇联合奥沙利铂及氟尿嘧啶与奥沙利铂联合氟尿嘧啶辅助化疗Ⅲ期胃癌D2根治术的疗效比较[J].徐州医科大学学报,2019,39(01):1-5.
