林晶

作者: 时间:2024-12-05 点击数:

基本信息

职称:副主任医师

职务:黑色素瘤/泌尿/骨和软组织肉瘤亚专科临时负责人、Ⅰ期病房临时负责人、内科一支部副书记

研究方向:肿瘤学、免疫学

电子邮件:423559148@qq.com

个人简介

林晶,女,副主任医师,福建省高层次C类人才,硕士生导师。毕业于福建医科大学本硕连读七年制,四川大学生物治疗国家重点实验室访问学者。主要从事黑色素瘤、泌尿肿瘤、软组织肿瘤以及消化系统恶性肿瘤的化疗、分子靶向治疗、免疫治疗、综合治疗及肿瘤患者的营养支持治疗。兼任中国抗癌协会黑色素瘤专委会常委、中国临床肿瘤学会(CSCO)黑色素瘤专家委员会委员、国家癌症中心国家肿瘤质控中心黑色素瘤质控专家委员会委员、北京科创医学发展基金会黑色素瘤专业委员会秘书、福建省抗癌协会第一届肿瘤免疫专业青年委员会委员、福建省免疫学会青年委员会第一届委员会委员。连续2021-2024年执笔参与编写《中国临床肿瘤学年度研究进展(黑色素瘤部分)》,《肝癌伴下腔静脉癌栓(内科治疗部分)》、《人干扰素α1b治疗黑色素瘤专家共识(2024版)》等。研究成果在ESMO、ASCO进行交流。2023年度指导福建医科大学大学生大创项目《黑色素瘤患者免疫联合治疗不良反应发生谱及相关性调研》获评国家级立项。2024年获得“福建省抗癌协会科技进步奖一等奖(4/10)”,“福建省肿瘤学术大会优秀论文“,“福建医科大学青年教师比赛三等奖”等。

主要科研项目

1.福建省科技厅自然科学基金项目,2023J011254,PRKDC基因关键位点变异影响DNA-PKcs功能与ICI疗效的相关性研究,2023/08/01-2026/08/01,8万元,主持

2.福建省卫生健康委员会,科技创新联合资金项目,2023Y9412,ZNF729、ZCCHC6基因突变作为肢端黑色素瘤候选新生抗原对免疫应答的机制与研究,2024/1/1-2027/1/1,50万元,主持

3.福建省科技厅自然科学基金项目,2017J01259,IFN-γ通过JAKs-STATs调节胃癌细胞PD-L1表达影响NKT细胞杀伤效应的机制研究,2017/04/01-2020/04/01,9万元,主持

4.福建省卫生厅青年课题,2016-1-11,STATs蛋白调节胃癌细胞PD-L1表达影响过继细胞免疫治疗疗效的机制研究,2016/10-2019/09,3万元,主持

近三年发表的主要论文

1.Zhang H, Lin J, Huang Y, Chen Y. The Systemic Immune-Inflammation Index as an Independent Predictor of Survival in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Radiotherapy. J Inflamm Res. 2024;17:4575-4586. (JCR2区,共一)

2.Lin J, Zhu L, Chen Y, et al. Based on Immune Microenvironment and Genomic Status, Exploring Immunotherapy in Advanced Hidradenocarcinoma: A Retrospective Analysis. Acta Derm Venereol. 2024;104:adv22146. Published 2024 May 13. (JCR1区,一作)

3.Jia, J., Mao, L., Lin, J. et al. Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate therapy. Front. Med. (2024). (共一,JCR1区)

4.Lin J, Lin ZQ, Zheng SC, Chen Y. Immune checkpoint inhibitor-associated gastritis: Patterns and management. World J Gastroenterol. 2024;30(14):1941-1948. (JCR2区,一作)

5.Chen L, Lin J, Wen Y, et al. A senescence-related lncRNA signature predicts prognosis and reflects immune landscape in HNSCC. Oral Oncol. 2024;149:106659.(JCR1区,共一)

6.Lin Z, Xiao H, Liu J, Chen L, Zhang H, Huang Y, Chen Y, Lin J. Clinical features and prognosis of cardiac metastatic tumors. BMC Cancer. 2023 Dec 15;23(1):1235.(JCR2区,通讯)

7.Zheng X, Lin J, Xiong J, et al. SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy. BMC Cancer. 2023;23(1):686. Published 2023 Jul 21.(JCR 2区,共一)

8.Jiang JK, Chen HS, Tang WF, Chen Y, Lin J. Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects. World J Gastrointest Oncol. 2023;15(1):171-185. (JCR 3区,通讯)

9.Lin J, Liu J, Hao SG, Lan B, Zheng XB, Xiong JN, Zhang YQ, Gao X, Chen CB, Chen L, Huang YF, Luo H, Yi YT, Yi X, Lu JP, Zheng XW, Chen G, Wang XF, Chen Y. An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy. Front Immunol. 2022 Nov 23;13:1022598.(JCR1区,一作)

10.Chen Y#, Zheng X#, Lin J#, et al. A high homologous recombination deficiency score is associated with poor survival and a non-inflamed tumor microenvironment in head and neck squamous cell carcinoma patients. Oral Oncol. 2022 May; 128:105860.(JCR1区,共一)

11.Guo Z#, Yuan Y#, Chen C#, Lin J#, Ma Q#, Liu G, Gao Y, Huang Y, Chen L, Chen LZ, Huang YF, Wang H, Li B, Chen Y, Zhang X. Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer. NPJ Precis Oncol. 2022 Jun 3;6(1):34.(JCR1区,共一)

12.Lin J, Guo Q, Guo Z, Lu T, Chen G, Lin S, Chen M, Chen C, Lu J, Zong J, Tang L, Chen Y, Pan J. Stereotactic body radiotherapy extends the clinical benefit of PD-1 inhibitors in refractory recurrent/metastatic nasopharyngeal carcinoma. Radiat Oncol. 2022 Jul 5;17 (1):117.(JCR 2区,一作)

13.Jun Liu, Jing Lin, Xuefeng Wang, Xiaobin Zheng, Xuan Gao, Yingying Huang, Gang Chen, Jiani Xiong, Bin Lan, Chuanben Chen, Lu Si and Yu Chen. CCND1 Amplification Profiling Identifies a Subtype of Melanoma Associated with Poor Survival and an Immunosuppressive Tumor Microenvironment. Front Immunol. 2022 Jul 1; 13: 725679.(JCR 1区,共一)

14.Lin J, Chen H, Huang Y, Tang W, Zhang S, Chen Y. Lack of Association Between PDCD-1 Polymorphisms and Colorectal Cancer Risk: A Case-Control Study. Immunol Invest. 2022 May 2:1-16.(JCR 3区,一作)

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