基本信息
职称：副教授、硕士生导师
研究方向：DNA结构设计及其应用研究
电子邮件：chenjielin@fzu.edu.cn
教育工作经历
2024.08— 至今，福州大学，副教授
2021.01—2024.08，上海交通大学，化学化工学院，博士后（合作导师：樊春海院士、刘小果研究员）
2018.09—2019.09，法国国家健康与医学研究院，联培博士（导师：Jean-Louis Mergny院士）
2015.09—2020.12，南京大学，化学化工学院，理学博士（导师：鞠熀先教授、周俊教授）
2011.09—2015.07，厦门大学，化学化工学院，理学学士（导师：杨朝勇教授）
主要科研项目
1、中国博士后科学基金面上项目（2021M702106），主持，2022年—2024年
2、福州大学高层次人才启动经费（511501），主持，2024年
3、生命分析化学国家重点实验室开放基金（SKLACLS2307），主持，2023年
4、国家自然科学基金面上项目（82370644），参与，2024年—2027年
5、国家自然科学基金面上项目（21977045），参与，2020年—2023年
获奖及荣誉
1、上海市“超级博士后”激励计划（2021年）
2、第二届化学生物学研究生前沿论坛最佳口头报告奖（2020年）
3、第七届四链核酸国际会议最佳海报奖（2019年）
4、国际遗传工程设计竞赛世界锦标赛金奖及Interlab单项奖（2014年）
近年发表的主要成果（†equal contribution）
1.Ziyu Li, Mingqiang Li, Xiaoguo Liu*,Jielin Chen*.Nano Research,2025, https://doi.org/10.26599/NR.2025.94907250.
2.Jielin Chen, Zheze Dai, Hui Lv, Zhongchao Jin, Yuqing Tang, Xiaodong Xie, Jiye Shi, Fei Wang, Qian Li, Xiaoguo Liu*, Chunhai Fan*. Programming crystallization kinetics of self-assembled DNA crystals with 5-methylcytosine modification.Proceedings of the National Academy of Sciences of the United States of America,2024,121, e2312596121.
3.Jielin Chen†, Mingpan Cheng†, Gilmar F. Salgado†, Petr Stadlbauer, Xiaobo Zhang, Samir Amrane, Aurore Guédin, Fangni He, Jiří Šponer, Huangxian Ju*, Jean-Louis Mergny*, Jun Zhou*. The beginning and the end: Role of flanking nucleotides on G-quadruplex topology.Nucleic Acids Research,2021,49, 9548-9559.
4.Jielin Chen, Yingying Zhang, Mingpan Cheng, Yuehua Guo, Jiří Šponer, David Monchaud, Jean-Louis Mergny, Huangxian Ju*, Jun Zhou*. How proximal nucleobases regulate the catalytic activity of G quadruplex/hemin DNAzymes.ACS Catalysis,2018,8, 11352-11361.
5.Jielin Chen†, Jiawei Wang†, Stephanie C. C. van der Lubbe†, Mingpan Cheng†,Dehui Qiu, David Monchaud, Jean-Louis Mergny,Célia Fonseca Guerra*, Huangxian Ju*, Jun Zhou*. A push-pull mechanism helps design highly competent G-quadruplex-DNA catalysts.CCS Chemistry,2020,2, 2183-2193.
6.Jielin Chen†, Mingpan Cheng†, Petr Stadlbauer, Jiří Šponer, Jean-Louis Mergny*, Huangxian Ju*, Jun Zhou*. Exploring sequence space to design controllable G-quadruplex topology switches.CCS Chemistry,2021,3, 3232-3246.
7.Jielin Chen†, Mingpan Cheng†, Jiawei Wang, Dehui Qiu, David Monchaud, Jean-Louis Mergny, Huangxian Ju*, Jun Zhou*. The catalytic properties of DNA G-quadruplexes rely on their structural integrity.Chinese Journal of Catalysis,2021,42, 1102-1107.
8.Jielin Chen†, Yuehua Guo†, Jun Zhou*, Huangxian Ju*. The effect of adenine repeats on G-quadruplex/hemin peroxidase mimicking DNAzyme activity.Chemistry - A European Journal,2017,23, 4210-4215.
9.Jielin Chen, Yingying Zhang, Mingpan Cheng, Jean-Louis Mergny, Qianmei Lin, Jun Zhou*, Huangxian Ju*. Highly active G-quadruplex/hemin DNAzyme for sensitive colorimetric determination of lead(II).Microchimica Acta,2019,186, 786.
10.Chengpin Liang†,Jielin Chen†, Mingqiang Li, Qian Li, Chunhai Fan*, Shihua Luo*, Jianlei Shen*. Programming the self-assembly of amphiphilic DNA frameworks for sequential Boolean logic functions.Chemical Communications,2022,58, 8786-8789.
11.Jianjun Xia†,Jielin Chen†, Jiahang Zhou, Mingpan Cheng, Xinzhe Zhuang, Chengfeng Cai, Huangxian Ju, Jean-Louis Mergny, Jun Zhou*. Antiparallel G-quadruplex formation hinders conversion to a parallel topology.The Journal of Physical Chemistry B,2024,128, 11077–11087.
12.Yuehua Guo,Jielin Chen, Mingpan Cheng, David Monchaud, Jun Zhou*, Huangxian Ju*. A thermophilic tetramolecular G-quadruplex/hemin DNAzyme.Angewandte Chemie International Edition,2017,56, 16636-16640.
13.Mingpan Cheng*,Jielin Chen, Huangxian Ju, Jun Zhou*, Jean-Louis Mergny*. Drivers of i DNA formation in a variety of environments revealed by four-dimensional UV melting and annealing.Journal of the American Chemical Society,2021,143, 7792-7807.
14.Xiaobo Zhang†, Dehui Qiu†,Jielin Chen, Yue Zhang, Jiawei Wang, Desheng Chen, Yuan Liu, Mingpan Cheng, David Monchaud, Jean-Louis Mergny, Huangxian Ju, Jun Zhou*. A chimeric biocatalyst combining peptidic and nucleic acid components overcomes the performance and limitations of the native horseradish peroxidase.Journal of the American Chemical Society,2023,145, 4517-4526.
15.Xiaoliang Chen, Yue Wang, Xinpei Dai, Longjiang Ding,Jielin Chen, Guangbao Yao, Xiaoguo Liu, Shihua Luo, Jiye Shi, Lihua Wang, Rachel Nechushtai, Eli Pikarsky, Itamar Willner, Chunhai Fan, Jiang Li*. Single-Stranded DNA-Encoded Gold Nanoparticle Clusters as Programmable Enzyme Equivalents.Journal of the American Chemical Society,2022,144, 6311-6320.
16.Mingpan Cheng, Dehui Qiu, Liezel Tamon, Eva Maturová, Pavlína Víšková, Samir Amrane, Aurore Guédin,Jielin Chen, Laurent Lacroix, Huangxian Ju, Lukáš Trantírek, Aleksandr B. Sahakyan, Jun Zhou*, Jean-Louis Mergny. Thermal and pH stabilities of i-DNA: confronting in vitro experiments with models and in-cell NMR data.Angewandte Chemie International Edition,2021,60, 10286-10294.
17.Yanjing Gao,Jielin Chen, Guorui Chen, Chunhai Fan*, Xiaoguo Liu*.Recent Progress in the Transfer of Graphene Films and Nanostructures.Small Methods,2021, 2100771.
18.Petr Stadlbauer*, Barira Islam, Michal Otyepka,Jielin Chen, David Monchaud, Jun Zhou, Jean-Louis Mergny, Jiří Šponer*. Insights into G-quadruplex-hemin dynamics using atomistic simulations: Implications for reactivity and folding.Journal of Chemical Theory and Computation,2021,17, 1883–1899.
19.Chengpin Liang,Jielin Chen, Mingqiang Li, Zhilei Ge, Chunhai Fan*, Jianlei Shen*. Probing the Self-assembly Process of Amphiphilic Tetrahedral DNA Frameworks.Chemical Communications,2022,58, 8352-8355.
20.Dehui Qiu†, Mingpan Cheng†, Petr Stadlbauer†,*,Jielin Chen, Michal Langer, Xiaobo Zhang, Qiang Gao, Huangxian Ju, Jiří Šponer, Jean-Louis Mergny, David Monchaud*, Jun Zhou*. The topology of DNA G-quadruplexes can be harnessed in Holliday junction-based DNA suprastructures to control and optimize their biocatalytic properties.ACS Catalysis,2023,13, 10722-10733.
21.Cong Li,Jielin Chen, Tiantian Man, Bin Chen, Jiang Li, Qian Li, Xiurong Yang, Ying Wan*, Chunhai Fan, Jianlei Shen*. DNA framework-engineered assembly of cyanine dyes for structural identification of nucleic acids.JACS Au,2024,4, 1125–1133.
22.Chengpin Liang, Qiuling Huang, Haoran Zheng, Mulin Duan, Xinyi Cheng,Jielin Chen, Qian Li, Zhiyun Zhang*, Chunhai Fan, He Tian, Jianlei Shen*. Probing Cell Membrane Tension Using DNA Framework-Encoded Vibration-Induced Emission Molecular Assemblies.Journal of the American Chemical Society,2024,146, 34341-34351.
