基本信息
职称：副主任医师
职务：福建省肿瘤医院医工交叉办公室副主任
研究方向：头颈部肿瘤基础与临床研究，人工智能影像组学研究
电子邮件：308466040@qq.com
个人简介
许昀，男，福建省肿瘤医院头颈放疗科主诊医师，副主任医师，副教授，医学博士，研究生导师。本科与硕士毕业于福建医科大学，博士毕业于天津医科大学。从事鼻咽癌、舌癌、口咽癌、下咽癌、喉癌、副鼻窦癌等头颈部恶性肿瘤的放射治疗、近距离后装放射治疗、三维适形调强、TOMO等精确放射治疗以及综合治疗。兼任中国抗癌协会肿瘤放射治疗专委会第三届青年委员会委员，中国抗癌协会近距离放射治疗专委会青年委员，中国抗癌协会第一届、第二届肿瘤热疗专业委员会委员，中国抗癌协会头颈肿瘤热疗专家委员会第一届委员，中国抗癌协会肿瘤营养专业委员会肿瘤营养科普专家协助组副组长，福建省抗癌协会鼻咽癌专业委员会青委会副主任委员，福建省抗癌协会肿瘤营养与支持治疗专业委员会青委会副主任委员，中国人体健康科技促进会鼻咽癌专业委员会委员，中日医学科技交流协会肿瘤粒子治疗技术专业委员会委员，中国营养保健食品协会特殊医学用途配方食品应用专业委员会第二届委员，福建省医学会放射肿瘤治疗学分会头颈肿瘤学组委员，福建省海峡医药卫生交流协会肿瘤营养分会常务理事，福建省癌症康复协会第一届专家委员会副主任委员，福建省肿瘤医院头颈肿瘤多学科综合诊疗小组秘书。在Oral Oncology、BMC cancer等国内外重要期刊发表多篇学术论文。主持福建省科技计划项目、福建省科技创新联合资金项目、福建省卫健委中青年骨干人才培养项目等多项省厅级课题。荣获福建省科技进步一等奖和福建省自然科学优秀论文三等奖。
主要科研项目
1、鼻咽癌调强放疗后甲状腺功能减退剂量体积参数研究和危险因素分析（2019Y0061），福建省科技厅引导性（重点）项目，主持
2、IGF2BP3通过PI3K/AKT/mTORC1通路促进鼻咽癌细胞转移的机制研究（2020GGB013）, 福建省卫健委中青年骨干人才培养项目，主持
3、基于磁共振影像组学对局部复发鼻咽癌再程放疗预后的研究（2021Y9207），福建省科技创新联合资金项目，主持
4、头颈部鳞状细胞癌微生物-基因网络的构建与功能解析（2024YNG08），福建省肿瘤医院第四高层次人才，主持
5、微生物组学视角下头颈部鳞癌的新型生物标志物挖掘与机制解析（2024J011077），省自然面上项目，主持
6、基于5hmC高通量检测的鼻咽癌表观遗传学标志物研究，（2021QN0101），福建省科技计划项目，第二承担人；
获奖经历
1、2018年，福建省科技进步奖一等奖
2、2018年，福建省自然科学优秀学术论文三等奖
近五年发表的主要论文
1.Chen, B., Zhan, Z., Fang, W., Zheng, Y., Yu, S., Huang, J., Pan, J., Lin, S., Guo, Q., &Xu, Y.(2024). Long-term trends and future projections of larynx cancer burden in China: a comprehensive analysis from 1990 to2030usingGBDdata.Scientificreports,14(1),26523.https://doi.org/10.1038/s41598-024-77797-6
2.Chen, B., Wang, D.,Xu, Y., Guo, Q., Pan, J., Yu, S., Fang, Y., Xiao, S., Ruan, Y., Yang, S., Lin, M., Hong, J., Zhan, Z., & Lin, S. (2024). 5-Hydroxymethylcytosines in circulating cell-free DNA as a diagnostic biomarker for nasopharyngeal carcinoma. European journal of cancer (Oxford,England :1990),210,114294.https://doi.org/10.1016/j.ejca.2024.114294
3.Yun Xu#, Hewei Peng#, Qiaojuan Guo, Lanyan Guo, Xiane Peng*, Shaojun Lin*. Effect of Percutaneous Endoscopic Gastrostomy on Quality of Life after Chemoradiation for Locally Advanced Nasopharyngeal Carcinoma: A Cross-Sectional Study. Current oncology (Toronto, Ont.).2023 Jan;30(1):1000–1009.
4.Yun Xu#, Zhoubo Guo#, Hewei Peng, Lanyan Guo, Ping Wang*. IGF2BP3 promotes cell metastasis and is associated with poor patient survival in nasopharyngeal carcinoma. Journal of cellular and molecular medicine. 2022 Jan;26(2):410-421.
5. Cheng Lin#, Sheng Lin, Lili Zhu, Shaojun Lin, Jianji Pan*,Yun Xu*. Optimizing the treatment mode for de novo metastatic nasopharyngeal carcinoma with bone-only metastasis. BMC cancer. 2022 Jan;22(1):35.
6.Yun Xu#, Mengwei Chen#, Qiaojuan Guo, Hewei Peng, Lanyan Guo, Jingfeng Zong, He Huang, Bijuan Chen, Hanchuan Xu, Jianji Pan, Shaojun Lin*. Percutaneous endoscopic gastrostomy can improve survival outcomes in patients with N3 nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy. Oral Oncology. 2021 Jul;121:105435.
7.Yun Xu, Hewei Peng, Guangjian Su , Yanming Cheng , Qiaojuan Guo , Lanyan Guo , XianE Peng ,Jiangfeng Ke. Thyroid V40 is a good predictor for subclinical hypothyroidism in patients with nasopharyngeal carcinoma after intensity modulated radiation therapy: a randomized clinicaltrial.RadiatOncol.2023Aug25;18(1):141.doi:10.1186/s13014-023-02329-x.
8.Jiesong Wang, Yun Xu, Wei Yu, Yanbin Zheng, Hongming He , Daoguang Chen , Siping Zou , Chang Wang , Ying Chen , Ningbin Chen , Hui Wu , Jianchao Wang, Jianyang Lin. Prognostic analysis of prostaglandin D2 synthase in difuse large B-cell lymphoma .2, 39 (2023).doi:https://doi.org/10.1007/s44178-023-00060-x.
9.许昀,郭岚晏,彭荷苇,林城,王杰松,庄晴阳,张瑜,林庆良.~(18)F-FDG PET/CT和MRI及血浆EB病毒水平对鼻咽癌局部复发的诊断价值研究[J].中国肿瘤临床,2022,49(21):1115-1120.
10.许昀,王杰松,苏光建,程燕铭,朱丽丽 彭荷苇.(2023).预防鼻咽癌根治性放疗后甲状腺功能减退的剂量-体积限制参数的外部验证.中国肿瘤临床(13),667-672.
11.Bijuan Chen, Zhouwei Zhan, Jianji Pan, Youping Xiao, Linbo Tang, Qiaojuan Guo,Yun Xu, Jingfeng Zong, Ruiting Zhang, Hanchuan Xu, Shaojun Lin*. Re-evaluation of the prognostic significance of retropharyngeal node metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. sia-Pacific journal of clinical oncology. 2022 Apr;18(2):e173-e181.
12. Qiaojuan Guo, Nan Xiao, Hanchuan Xu, Jingfeng Zong, Youping Xiao, Tianzhu Lu,Yun Xu, Bingyi Wang, Bijuan Chen, Jianji Pan, Shaojun Lin*. Level Ib sparing intensity-modulated radiation therapy in selected nasopharyngeal carcinoma patients based on the International Guideline. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2022 Feb;167:239-243.
13. Jing-Feng Zong#, Qian-Dong Liang#, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu, Bi-Juan Chen, Qiao-Juan Guo,Yun Xu, Cai-Rong Hu, Jian-Ji Pan, Shao-Jun Lin*. Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma. BMC cancer. 2021 Nov 25;21(1):1274.
14. Hanchuan Xu, Lihu Lu, Tianzhu Lu,Yun Xu, Jingfeng Zong, Chaobin Huang, Fengjie Lin, Yahan Zheng, Cheng Lin, Senan Lin, Sufang Qiu, Jianji Pan, Shaojun Lin, Qiaojuan Guo*. Identifying the optimal candidates for locoregional radiation therapy in patients with de novo metastatic nasopharyngeal carcinoma. Head Neck. 2021 Sep;43(9):2602-2610.
15. Jingfeng Zong, Yuhong Liu, Qiandong Liang, Hanchuan Xu, Bijuan Chen, Qiaojuan Guo,Yun Xu, Cairong Hu, Jianji Pan, Shaojun Lin*. Administration of oral maintenance chemotherapy for 1 year following definitive chemoradiotherapy may improve the survival of patients with stage N3 nasopharyngeal carcinoma. Oral Oncology. 2021 Jul;118:105313.
16. Qiaojuan Guo, Yahan Zheng, Jinyong Lin,Yun Xu, Cairong Hu, Jingfeng Zong, Tianzhu Lu, Hanchuan Xu, Bijuan Chen, Qiandong Liang, Youping Xiao, Jianji Pan, Shaojun Lin*. Modified reduced-volume intensity-modulated radiation therapy in non-metastatic nasopharyngeal carcinoma: A prospective observation series. Radiotherapy and Oncology. 2021 Mar;156:251-257.
17. Shichuan Zhang, Shuang Yang, Peng Xu,Yun Xu, Guanqun Zhou, Xiaomin Ou, Runye Wu, Mei Lan, Davide Fontanarosa, Jason Dowling, Xiaoshen Wang, Shaojun Lin, Jun-Lin Yi, Ying Sun, Chaosu Hu, Jinyi Lang*. Variations of Clinical Target Volume Delineation for Primary Site of Nasopharyngeal Cancer Among Five Centers in China. Frontiers in Oncology. 2020 Aug 20;10:1572.
18. Han Zhou, Tianzhu Lu, Qiaojuan Guo, Yan Chen, Mengwei Chen, Yansong Chen, Yingying Lin, Chuanben Chen, Liqin Ma,Yun Xu, Shaojun Lin, Jianji Pan*. Effects of oral maintenance chemotherapy and predictive value of circulating EBV DNA in metastatic nasopharyngeal carcinoma. Cancer Medicine. 2020 Apr;9(8):2732-2741.
19. Qiaojuan Guo#, Mengwei Chen#, Hanchuan Xu, Tianzhu Lu, Han Zhou, Yanyan Chen, Jingfeng Zong,Yun Xu, Bijuan Chen, Bingyi Wang, Lili Zhu, Jianji Pan, Shaojun Lin*. Oral Maintenance Chemotherapy Using S-1/Capecitabine in Metastatic Nasopharyngeal Carcinoma Patients After Systemic Chemotherapy: A Single-Institution Experience. Cancer Management Research. 2020 Feb 25;12:1387-1396.
20. Huocong He#, Shuo Qie#, Qiaojuan Guo, Shuyang Chen, Changyan Zou, Tianzhu Lu, Ying Su, Jingfeng Zong, Hanchuan Xu, Dan He,Yun Xu, Bijuan Chen, Jianji Pan, Nianli Sang, Shaojun Lin*. Stanniocalcin 2 (STC2) expression promotes post-radiation survival, migration and invasion of nasopharyngeal carcinoma cells. Cancer Management and Research. 2019 Dec 11;11:10409.
21. Jingfeng Zong, Hanchuan Xu, Bijuan Chen, Qiaojuan Guo,Yun Xu, Chuanben Chen, Youliang Weng, Wei Zheng, Jianji Pan, Shaojun Lin*. Maintenance chemotherapy using S-1 following definitive chemoradiotherapy in patients with N3 nasopharyngeal carcinoma. Radiation Oncology. 2019 Oct 22;14(1):182.
22. 陈碧娟,潘建基,郭巧娟,宗井凤,许昀,林少俊*.调强放疗时代咽后淋巴结与鼻咽癌预后关系的研究[J].实用癌症杂志,2019,34(10):1639-1642.
