基本信息

职称：副教授、主任医师

职务：福建省肿瘤医院副院长

研究方向：介入治疗相关新型材料、肝癌转移机制及综合介入治疗

电子邮件：470389481@qq.com

个人简介

方主亭，男，医学博士，博士研究生导师，省级C类高层次人才。主要从事肝癌综合介入治疗（包括化疗栓塞术、动脉化疗灌注术、肿瘤射频消融治疗、靶向免疫治疗）、其他肿瘤介入治疗（头颈部、胸腹部、盆腔等肿瘤介入治疗）、肝硬化食管静脉曲张破裂出血(TIPS）、门脉癌栓的微创介入治疗、子宫肌瘤和腺肌症、前列腺增生介入治疗以及外周血管介入治疗（动脉闭塞、血栓、动脉瘤、下肢静脉血栓、静脉曲张等）。

兼任福建医师协会介入放射科医师分会会长、福建介入创新联盟理事长、福建省抗癌会肿瘤介入学专业委员会副主任委员、福建医学会介入分会副主任委员、中国抗癌协会诊疗一体化专业委员会常务委员、中国抗癌协会肿瘤微创委员会委员、中国医师协会介入医师分会委员。

主持或参与“十四五”国家重点研发计划、国家自然科学基金面上项目、福建省自然科学基金项目、福建省卫健委中青年骨干课题等数项。《中华介入放射学电子杂志》编委。获福建省医学科技奖三等奖1项，福建省抗癌协会科技进步奖三等奖1项，主译专著1部，副主编1部，参编3部。

主要科研项目

1、国产高端低剂量DSA/CT-DSA功能创新及介入诊疗应用研究，国家重点研发计划，“诊疗装备与生物医用材料”重点专项，2023YFC2413500，2023.11~2026.10，在研，参与；

2、去甲基化酶ALKBH5介导的circSCAF11 m6A修饰通过增强HIF1A转录促进肝细胞癌转移的机制研究，福建省自然科学基金面上项目，2024J01122229，2024.11~2027.4，主持；

3、可形变载药微球在肝癌介入治疗中的应用，福建省科技创新联合资金项目，2023Y9320，2024.01~2026.1，主持

获奖经历

1、2022年度福建省医学科技奖三等奖（第一完成人）

2、2024年度福建省抗癌协会科技进步奖三等奖（第一完成人）

近三年发表的主要论文

1.Ni Jia-Yan,Fang Zhu-Ting,Sun Hong-Liang,et al:A nomogram to predict survival of patients with intermediate-stage hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation:European radiology:2020;30 (4)：2377-2390

2.Li Chen,Han-Lu Wang,Yao-Bin Zhu,Zhao Jin,Jian-Bin Huang,Xin-Fu Lin,Jie-Wei Luo,Zhu-Ting Fang,et al:Screening and function discussion of a hereditary renal tubular acidosis family pathogenic gene:Cell death & disease:2020;11 (3)：159

3.Yi Tang, Jian-Hui Zhang, Yao-bin Zhu, Shao-Jie Wu, Sen-Lin Cai, Yan-Feng Zhou, Xin Qian, Jie-Wei Luo,Zhu-Ting Fang,et al:Effect of superselective prostatic artery embolization on benign prostatic hyperplasia: Abdominal radiology:2021;46 (4)：1726-1736

4.Yan-Ping Zhang,Bin Lin, Yuan-Yuan Ji, Ya-Nan Hu, Xin-Fu Lin, Yi Tang, Jian-Hui Zhang, Shao-Jie Wu,Sen-Lin Cai, Yan-Feng Zhou, Ting Chen,Zhu-Ting Fang, Jie-Wei Luo, et al: A thrombophilia family with protein S deficiency due to protein translation disorders caused by a Leu607Ser heterozygous mutation in PROS1:Thrombosis journal:2021;19 (1)：64

5.Yi Tang,Ruo-Li Wang,Dan-Dan Ruan,Xin Chen,Yan-Feng Zhou,Shao-Jie Wu,Sen-Lin Cai,Jian-Hui Zhang,Feng-Guang Yang, Jie-Wei Luo,Zhu-Ting Fang, et al: Retrospective observation of the efficacy and safety of prostatic artery embolization combined with transurethral resection of the prostate and simple transurethral resection of the prostate in the treatment of large (> 100 mL) benign prostatic hyperplasia: Abdominal radiology:2021;46 (12)：5746-5757

6.Wang RL, Fu QT, Jiang J, Ruan DD, Lin JL, Tang Y, Zhou YF, Wu SJ, Cai SL, Zhang JH, Luo JW,Fang ZT. Clinical outcomes of uterine artery embolization and experience of postoperative transvaginal fibroid expulsion: a retrospective analysis. Arch Gynecol Obstet. 2022 Sep;306(3):829-840.

7.Jia-Li Lin, Yuan-Yuan Ji, Ming-Zhe Zhang, Yi Tang, Ruo-Li Wang, Dan-Dan Ruan, Yan-Feng Zhou, Shao-Jie Wu, Sen-Lin Cai, Jian-Hui Zhang, Xiao-Rong Meng, Jie-Wei Luo andZhu-Ting Fang.Rare Cases of Bronchial Aneurysm and Comparison of Interventional Embolization in the Treatment of True Bronchial Aneurysm and Pseudobronchial Aneurysm，Front. Cardiovasc. Med., 09 March 2022

8.Xian Pan, Han-Lu Wang, Shi-Ming Lin, Jia-Li Lin, Dan-Dan Ruan, Jian-Hui Zhang, Ting Chen, Jie-Wei Luo,Zhu-Ting Fang. A Primary Extraskeletal Osteosarcoma of the Spleen: Rare Case Report. Front Oncol. 2022 May 2;12:892943.

9.Yanfeng Zhou, Jingyi Chen, Pingzhou Chen, Yi Tang, Shaojie Wu, Senlin Cai,Zhuting Fang. Super-selective transcatheter vesical arterial chemoembolization with drug-loaded beads for muscle-invasive bladder cancer with hematuria. Abdom Radiol (NY). 2023 Feb;48(2):780-786.

10.Jia-Li Lin, Can Lin, Han-Lu Wang, Shao-Jie Wu, Yi Tang, Chang Shun Yang, Jie-Wei Luo, Wu Chi,Zhu-Ting Fang. Splenic Artery Embolization and Splenectomy for Spontaneous Rupture of Splenic Hemangioma and Its Imaging Features. Front Cardiovasc Med. 2022 Jun 3;9:925711.

11.Han-Lu Wang, Jian-Hui Zhang, Yi-Cheng Wu, Jia-Li Lin, Yi Tang, Li-Sheng Liao, Jie-Wei Luo, Qing-Hua Yu,Zhu-Ting Fang. Case report and analysis: Behçet's disease with lower extremity vein thrombosis and pseudoaneurysm. Front Immunol. 2022 Aug 29;13:949356.

12.Han-Lu Wang , Dan-Dan Ruan, Min Wu, Yuan-Yuan Ji , Xing-Xing Hu, Qiu-Yan Wu, Yan-Ping Zhang, Bin Lin, Ya-Nan Hu, Hang Wang, Yi Tang,Zhu-Ting Fang, Jie-Wei Luo, Li-Sheng Liao, Mei-Zhu Gao. Identification and characterization of two SERPINC1 mutations causing congenital antithrombin deficiency. Thromb J. 2023 Jan 9;21(1):3.

13.Xian Pan, Shao-Jie Wu, Yi Tang, Yan-Feng Zhou, Jie-Wei Luo,Zhu-Ting Fang.Safety and Efficacy of Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitor and Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma: A Single Center Experience. J Hepatocell Carcinoma. 2023;10:883-892.

14.Shao-Jie Wu, Dan-Dan Ruan, Qiu-Yan Wu, Yi Tang, Jian-Hui Zhang, Sen-Lin Cai, Yan-Feng Zhou, Jie-Wei Luo,Zhu-Ting Fang. Safety and Efficacy of Drug-Eluting Bead Transarterial Chemoembolization Combined with Lenvatinib and Anti-PD-1 Antibodies for Unresectable Hepatocellular Carcinoma: A Retrospective Analysis. J Hepatocell Carcinoma. 2023 Jun 2;10:807-820.

15.Wu SJ, Zhang C, Wu M, Ruan DD, Zhang YP, Lin B, Tang Y, Chen X, Wang C, Pan HH, Zhu QG, Luo JW, Ye LF,Fang ZT. Pharmarcomechanical thrombectomy combined with transluminal balloon angioplasty for treating transplant renal vein thrombosis. Sci Rep. 2023 Oct 12;13(1):17303.

16.Lu T, Lin B, Zhang YP, Zhang JH, Luo JW, Tang Y,Fang ZT. Eighteen cases of renal aneurysms: Clinical retrospective analysis and experience of endovascular interventional treatment. Front Surg. 2023 Feb 28;10:1106682.

17.Wu YL, Yang GK, Chen Q, Tang Y, Zhang JH, Wu SJ, Cai SL, Zhou YF, Zhu YB, Luo JW,Fang ZT. Case Report: Imaging features of a new type double inferior vena cava malformation and review. Front Cardiovasc Med. 2023 Dec 4;10:1298071.

18.Hu X,Fang Z, Sun F, et al. Deciphering Oxygen-Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron-Hole Pairs. Angew Chem Int Ed Engl. 2024;63(15):e202401036.

19.Xiaoming Hu,Zhuting Fang, Caijun Zhu , Yanling Yang , Zhen Yang , Wei Huang. Crucial Breakthrough of BODIPY-Based NIR-II Fluorescent Emitters for Advanced Biomedical Theranostics. Advanced Functional Materials.

20.Wang RL, Lin FF, Ruan DD, Li SJ, Zhou YF, Luo JW,Fang ZT, Tang Y. A correlation study between prostate necrosis rate calculated by 3D Slicer software and clinical efficacy of prostatic artery embolization, along with an analysis of predictors of clinical success after prostatic artery embolization. Abdom Radiol (NY). 2024 Mar;49(3):927-938.

21.Jingjing Zhao, Qiaojuan Li, Jia Hu, Hongwu Yu, Youmin Shen, Hongyan Lai, Qin Li, Hena Zhang, Yan Li,Zhuting Fang, Shenglin Huang.Circular RNA landscape in extracellular vesicles from human biofluids.Genome Medicine.2024 Oct 31;16(1):126.

22.Caijun Zhu, Mingdian Yu, Jingqi Lv, Fengwei Sun, Achen Qin, Zejing Chen, Xiaoming Hu, Zhen Yang,Zhuting Fang,De novo strategy of organic semiconducting polymer brushes for NIR-II light-triggered carbon monoxide release to boost deep-tissue cancer phototheranostics, 2024,Doi:10.1186/s12951-024-02984-6