基本信息
职称：二级主任医师
职务：放疗科党总支部书记、头颈放疗科主任
研究方向：智能信息处理、生物医用材料
电子邮件：sfqiu@126.com
个人简介
邱素芳，放疗科党总支部书记、头颈肿瘤放疗科行政主任、二级主任医师、鼻咽癌诊治中心执行主任、肿瘤学博士、教授、博士研究生导师、福建省高层次人才（C类）、福建省卫生健康突出贡献中青年专家、国家肿瘤放射治疗临床重点学科、省肿瘤转化医学重点实验室成员等。30年来专业从事头颈部恶性肿瘤的放射治疗、三维适形调强放疗、TOMO放疗以及化疗、生物免疫靶向等综合治疗及相关基础和临床研究，带领并指导课题组开展创新性研究工作。
临床方面，近5年门诊人次数13780人，住院人次数6382人，医德医风高尚，广受患者及家属的赞誉。2018年起牵头举办院内精品讲座“垒土沙龙”学术活动，至今达137期，培养一大批优秀的中青年骨干，同时扩大医院影响力，推动学科发展与进步。
长期从事鼻咽癌的基础研究与临床工作，针对鼻咽癌治疗异质性，提出鼻咽癌新的分子分型，推动鼻咽癌精准治疗和预后的预测。针对复发转移性鼻咽癌的治疗难点及重点，在国内率先构建了复发鼻咽癌的精准调强放疗技术体系，研究成果在国内外得到广泛推广应用，已被42家省级及地市级医院应用，获益的鼻咽癌达40000例以上，不良反应明显减轻，患者生存质量明显改善。参编国内首个《鼻咽癌标志物临床应用专家共识》，该共识在全国推广应用，为鼻咽癌标志物的开发和应用提供了权威的参考。作为多项国内外多中心临床研究PI，造福了广大鼻咽癌患者，产生了良好的社会效益。
至今在国内外发表论文70余篇，其中SCI 50余篇，最高影响因子11.55（中科院1区Top期刊）。主持国家重点项目、国自然面上项目、福建省自然重点项目等20余项课题，目前在研课题经费近千万元。荣获福建省科技进步一、二等奖，福建医学科技奖及福建省抗癌协会科技进步奖等。被聘为多个国际专业学术期刊的审稿专家和国自然科学基金函审专家。兼任中国抗癌协会肿瘤标志专业委员会鼻咽癌标志物专家委员会副主任委员、中国抗癌协会放射医学专业委员会常务委员、福建省医学会放射肿瘤专委会副主委、福建省抗癌协会头颈肿瘤专业委员会副主委、福建省抗癌协会放射肿瘤专业委员会常委等。
教学方面，作为福建医科大学及福州大学教授、博士生导师及放射医学教研室主任，共培养硕士20余名，博士6名，多次获得福建医科大学校级“优秀教师”称号。参与审译国际放疗教科书第5版《放射肿瘤学原理和实践》；参编国家卫健委住院医师规范化培训规划教材第2版《肿瘤放射治疗学》；参编“十一五”国家级本科教材第3版《放射肿瘤学》，为放射肿瘤治疗领域的后备人才培养做出贡献。
主要科研项目
1.主持国家自然科学基金面上项目“钙调蛋白激酶PNCK介导鼻咽癌放疗抵抗及其机制研究”（82072986，55万元）
2.主持福建省卫生健康中青年科研重大项目“鼻咽癌微环境图谱的刻画及免疫治疗标记物的挖掘”（2021ZQNZD010，300万元）
3.主持福建省科技联合创新重大项目“复发转移性鼻咽癌微环境刻画及生物标记物挖掘”（2021Y9196，300万元）
4.主持福建省肿瘤医院高层次人才培养项目“外泌体在难治性鼻咽癌免疫治疗抵抗中的作用及机制研究”（2022YNG07，200万元）
5.参与国自然科学基金面上项目“基于血液循环外泌体SERS多级放大技术的鼻咽癌筛查研究”（11974077，合作方负责人）
6.主持国自然科学基金面上项目“PICK1调控花生四烯酸代谢促进鼻咽癌放疗抵抗的机制研究”（8247100212，55万元）
获奖经历
1、2023年，鼻咽癌转移分子标志物的机制研究和关键检测技术的转化应用，福建省抗癌协会科技进步奖二等奖（第七）
2、2021年，鼻咽癌诊疗新技术的系列研究及应用，福建省科技进步奖一等奖（第二）
3、2020年，基于拉曼光谱技术的鼻咽癌无创筛查新方法及鼻咽癌临床诊疗研究，福建省抗癌协会科技进步奖三等奖（第一）
4、2020年，鼻咽癌的无损诊断及复发的诊疗研究，福建医学科技奖二等奖（第一）
5、2020年，拉曼光谱检测技术研发与应用，福建省科学技术进步奖二等奖（第六）
6、2017年，基于MRI的鼻咽癌临床分期和精确放疗的应用研究，福建省科技进步一等奖（第八）
近五年发表的主要论文
1.Lin W, Xu Y, Chen X, Liu J, Weng Y, Zhuang Q, Lin F, Huang Z, Wu S, Ding J, Chen L, Qiu X, Zhang L, Wu J, Lin D,Qiu S. Radiation-induced small extracellular vesicles as “carriages” promote tumor antigen release and trigger antitumor immunity. Theranostics. 2020 Mar 26;10(11):4871-4884. doi: 10.7150/thno.43539. PMID: 32308755; PMCID: PMC7163438.（中科院1区TOP期刊，IF: 11.6分，通讯作者）
2.Ding Q, Weng Y, Li Y, Lin W, Lin X, Lin T, Yang H, Xu W, Wang J, Ying H,Qiu S. Inhibition of PNCK inflames tumor microenvironment and sensitizes head and neck squamous cell carcinoma to immune checkpoint inhibitors. J Immunother Cancer. 2024 Oct 12;12(10):e009893. doi: 10.1136/jitc-2024-009893. PMID: 39395840; PMCID: PMC11474745.（中科院1区TOP期刊，IF：10.3，通讯作者）
3.Qiu SF, Zhang QZ, Wu ZY, Liu MZ, Ding Q, Sun FM, Wang Y, Yang HX, Zheng L, Chen X, Wu L, Bai J, Liu JF, Chen CB. Establishment and validation of circulating cell-free DNA signatures for nasopharyngeal carcinoma detection. EBioMedicine. 2024 Oct;108:105321. doi: 10.1016/j.ebiom.2024.105321. Epub 2024 Sep 11. PMID: 39265506; PMCID: PMC11416236.（中科院1区TOP期刊，IF 9.7，第一作者）
4.Lin W, Chen X, Huang Z, Ding Q, Yang H, Li Y, Lin D, Lin J, Zhang H, Yang X, Li C, Chen C,Qiu S. Identification of novel molecular subtypes to improve the classification framework of nasopharyngeal carcinoma. Br J Cancer. 2024 Jan 27. doi: 10.1038/s41416-024-02579-w.（中科院1区TOP期刊，IF: 8.8，通讯作者）
5.Wu Q, Ding Q, Lin W, Weng Y, Feng S, Chen R, Chen C,Qiu S, Lin D. Profiling of tumor cell-delivered exosome by surface enhanced Raman spectroscopy-based biosensor for evaluation of nasopharyngeal cancer radioresistance. Adv Healthc Mater. 2022 Dec 17:e2202482. doi: 10.1002/adhm.202202482. Epub ahead of print. PMID: 36528342.（中科院1区，IF: 11.092分，通讯作者）
6.Weng S, Lin D, Lai S, Tao H, Chen T, Peng M,Qiu S, Feng S. Highly sensitive and reliable detection of microRNA for clinically disease surveillance using SERS biosensor integrated with catalytic hairpin assembly amplification technology. Biosens Bioelectron. 2022 Jul 15;208:114236. doi: 10.1016/j.bios.2022.114236. Epub 2022 Apr 1. PMID: 35381457.（中科院1区，IF: 12.545分，共同通讯作者）
7.Fan M, Weng Y, Liu Y, Lu Y, Xu L, Ye J, Lin D,Qiu S, Feng S. Surface-Enhanced Raman Spectroscopy-Based Optical Biosensor for Liquid Biopsy: Toward Precision Medicine, LASER &PHOTONICS REVIEWS, 2024, 2301072: 1-19.（共同通讯，中科院1区TOP期刊，IF: 11.0分，共同通讯作者）
8.Huang Z, Li Y, Hong W, Chen X, Pan Y, Weng Y, Liu W, Wang L,Qiu S. Identification of a ferroptosis-associated gene signature and the related therapeutic targets in head and neck squamous carcinoma. Int Immunopharmacol. 2022 Jan;102:108431. doi: 10.1016/j.intimp.2021.108431. Epub 2021 Dec 11. PMID: 34906855.（中科院2区，IF: 5.714分，通讯作者）
9.Li Y, Chen X, Wu L, Huang Z, Xu S, Hong X, Lai J, Qiu S, Zheng X. Impact of the radiotherapy rhythm on prognosis in nasopharyngeal carcinoma. Ann Med. 2024 Dec;56(1):2407061. doi: 10.1080/07853890.2024.2407061. Epub 2024 Sep 23. PMID: 39310946; PMCID: PMC11421160.（中科院2区，IF：4.9，通讯作者）
10.Ding Q, Lin F, Huang Z, Li Y, Cai S, Chen X, Liu H,Qiu S. Non-coding RNA-related FCGBP downregulation in head and neck squamous cell carcinoma: a novel biomarker for predicting paclitaxel resistance and immunosuppressive microenvironment. Sci Rep. 2024 Feb 23;14(1):4426. doi: 10.1038/s41598-024-55210-6. PMID: 38396056; PMCID: PMC10891054.（中科院2区，IF：3.8，通讯作者）
11.Weng Y, Cai S, Li C, Xu Y, Pan Y, Huang Z, Li Y, Wu Z, Chen Y,Qiu S. Selection of induction chemotherapy cycles for stage N3 nasopharyngeal carcinoma based on pre-treatment plasma EBV DNA. Sci Rep. 2024 Oct 18;14(1):24484. doi: 10.1038/s41598-024-75396-z. PMID: 39424840; PMCID: PMC11489564.（中科院2区，IF：3.8，通讯作者）
12.Pan Y, Zhang L, Xu S, Li Y, Huang Z, Li C, Cai S, Chen Z, Lai J, Lu J,Qiu S.Development and validation of a nomogram for predicting overall survival of head and neck adenoid cystic carcinoma. Sci Rep. 2024 Nov 2;14(1):26406. doi: 10.1038/s41598-024-77322-9. PMID: 39488563; PMCID: PMC11531573.（中科院2区，IF：3.8，通讯作者）
13.Weng Y, Wu L, Li Y, Wang J, Wu Z, Hong X, Liu X, Lai J, Lu J,Qiu S.Prognostic value of immune-inflammatory and nutrition indicators in non-metastatic nasopharyngeal carcinoma with negative plasma Epstein-Barr virus DNA. Ther Adv Med Oncol. 2024 Oct 14;16:17588359241286489. doi: 10.1177/17588359241286489. PMID: 39403452; PMCID: PMC11472370.（中科院2区，IF：4.3，通讯作者）
14.Li Y, Huang Z, Zeng X, Pan Y, Wu L, Wang J, Chen R, Xie Y, Lai J, Lin D, Qiu S.Early recurrence as a pivotal event in nasopharyngeal carcinoma: identifying predictors and key molecular signals for survivors. Head Face Med. 2024 Sep 28;20(1):55. doi: 10.1186/s13005-024-00457-7. PMID: 39342276; PMCID: PMC11438418.
15.Lin D, Wu W, Huang Z, Xu S, Li Y, Chen Z, Li Y, Lai J, Lu J,Qiu S. Comparative evaluation of machine learning models in predicting overall survival for nasopharyngeal carcinoma using 18F-FDG PET-CT parameters. Clin Transl Oncol. 2024 Sep 20. doi: 10.1007/s12094-024-03709-9. Epub ahead of print. PMID: 39304599.
16.Ding Q, Xu W, Yang H, Wu W, Wu L, Chen X, Liu H,Qiu S. The causal impact of complement C3d receptor 2 on head and neck cancer microenvironment and its implications for immunotherapy response prediction. Heliyon. 2024 Apr 6;10(7):e29312.
17.Li Y, Pan Y, Huang Z, Wu L, Wu W, Xu S, Chen Z, Chen X, Lu J,Qiu S. Comorbidity profiling identifies potential subtype of elderly patients with nasopharyngeal carcinoma. Oncologist. 2024 Apr 16:oyae063.
18.Pan Y, Chen Z, Hong W, Huang Z, Li Y, Cai S, Lai J, Lu J,Qiu S. A nomogram based on nutritional and inflammatory parameters to predict DMFS and identify beneficiaries of adjuvant chemotherapy in IVA-stage nasopharyngeal carcinoma. BMC Cancer. 2024 May 11;24(1):578.
19.Huang Z, Chen Z, Li Y, Lin T, Cai S, Wu W, Wu L, Xu S, Lu J,Qiu S.Machine learning-based survival prediction nomogram for postoperative parotid mucoepidermoid carcinoma. Sci Rep. 2024 Apr 1;14(1):7686.
20.LinD, HsiehCL, HsuKJ, LiaoPH,QiuS, GongT, YongKT, FengS, Voon KongK. Geometrically Encoded SERS Nanobarcodes for the Logical Detection of Nasopharyngeal Carcinoma-related Progression Biomarkers. Nat Commun. 2021 Jun 8;12(1):3430. doi: 10.1038/s41467-021-23789-3.PMID: 34078895; PMCID: PMC8173014.
21.Lin D, Yang SW, Hsieh CL, Hsu KJ, Gong T, Wu Q,Qiu S, Feng S, Kong K. Tandem Quantification of Multiple Carbohydrates in Saliva Using Surface-Enhanced Raman Spectroscopy. 2021 Mar 26;6(3):1240-1247. doi: 10.1021/acssensors.0c02533.PMID: 33867833; PMCID: PMC8040311.
22.SunY, WangZ,QiuS, WangR. Therapeutic strategies of different HPV status in Head and Neck Squamous Cell Carcinoma. Int J Biol Sci. 2021 Mar 10;17(4):1104-1118. doi: 10.7150/ijbs.58077.PMID: 33867833; PMCID: PMC8040311.
23.LiY, WengY, PanY, HuangZ, ChenX, HongW, LinT, WangL, LiuW,QiuS. A Novel Prognostic Signature Based on Metabolism-Related Genes to Predict Survival and Guide Personalized Treatment for Head and Neck Squamous Carcinoma. Front Oncol. 2021 Jun 14;11:685026. doi: 10.3389/fonc.2021.685026.PMID: 34195087; PMCID: PMC8236898.
24.ChenX, LiC, LiY, WuS, LiuW, LinT, LiM, WengY, LinW,QiuS. Characterization of METTL7B to Evaluate TME and Predict Prognosis by Integrative Analysis of Multi-Omics Data in Glioma. Front Mol Biosci. 2021 Sep 17;8:727481. doi: 10.3389/fmolb.2021.727481. PMID: 34604305;PMCID: PMC8484875.
25.HuangZ, LiY, HongW, ChenX, PanY, WengY, LiuW, WangL,QiuS. Identification of a ferroptosis-associated gene signature and the related therapeutic targets in head and neck squamous carcinoma. Int Immunopharmacol. 2022 Jan;102:108431. doi: 10.1016/j.intimp.2021.108431. PMID: 34906855.
26.LinW,XuY,Chen X, Liu J,WengY,Zhuang Q, LinF,Huang Z,WuS, Ding J, Chen L, Qiu X, Zhang L,WuJ, Lin D,Qiu S. Radiation-induced small extracellular vesicles as "carriages" promote tumor antigen release and trigger antitumor immunity. Theranostics. 2020 Mar 26;10(11):4871-4884. doi: 10.7150/thno.43539. PMID: 32308755; PMCID: PMC7163438.
27.LinW,WuS, Chen X,YeY,WengY,PanY,Chen Z, Chen L, Qiu X,Qiu S. Characterization of Hypoxia Signature to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Glioma Groups. Front Oncol. 2020 May 15;10:796. doi: 10.3389/fonc.2020.00796. PMID: 32500034; PMCID:PMC7243125.
28.LinW,Huang Z, XuY,Chen X, ChenT,YeY,Ding J, Chen Z, Chen L, Qiu X,Qiu S. A three-lncRNA signature predicts clinical outcomes in low-grade glioma patients after radiotherapy. Aging (Albany NY). 2020 May 26;12(10):9188-9204. doi: 10.18632/aging.103189. PMID: 32453707; PMCID:PMC7288909.
29.LinW,Chen X, ChenT,Liu J,YeY,Chen L, Qiu X, Chia-Hsien Cheng J, Zhang L,WuJ,Qiu S. C1QTNF6 as a Novel Diagnostic and Prognostic Biomarker for Clear Cell Renal Cell Carcinoma. DNA Cell Biol. 2020 Jun;39(6):1000-1011. doi: 10.1089/dna.2019.5299. Epub 2020 Apr 13. PMID:32282241.
30.Qiu S, Weng Y, Li Y, Chen Y, Pan Y, Liu J, Lin W, Chen X, Li M, Lin T, Liu W, Zhang L, LinD. (2020). Raman profile alterations of irradiated human nasopharyngeal cancer cells detected with laser tweezer Raman spectroscopy. RSC Advances. 2020; 10:14368-14373. doi: 10.1039/D0RA01173H.
31.Qiu S, Li M, Liu J, Chen X, LinT,XuY,ChenY,WengY,PanY,Feng S, Lin X, Zhang L, Lin D. Study on the chemodrug-induced effect in nasopharyngeal carcinoma cells using laser tweezer Raman spectroscopy. Biomed. Opt. Express 2020;11:1819-1833.
32.Lin X,WuQ, Lin J, Liu X, Jia X, Peng M, Lin D,Qiu S, Feng S. Label-free liquid biopsy based on urine analysis using surface-enhanced Raman spectroscopy for noninvasive gastric and breast cancer detection. Journal of Raman Spectroscopy. 2020 Aug;51(11):2245-2254. doi:10.1002/jrs.5978.
33.LinW,Liu J, Chen J, Li J,Qiu S, Ma J, Lin X, Zhang L,WuJ. Peptides of tetraspanin oncoprotein CD151 trigger active immunity against primary tumour and experimental lung metastasis. EBioMedicine. 2019 Nov;49:133-144. doi: 10.1016/j.ebiom.2019.10.025. Epub 2019 Oct 25. PMID:31668880.
34.Lin D,WuQ,Qiu S, Chen G, Feng S, Chen R, Zeng H. Label-free liquid biopsy based on blood circulating DNA detection using SERS-based nanotechnology for nasopharyngeal cancer screening. Nanomedicine. 2019 Oct 21;22:102100. doi: 10.1016/j.nano.2019.102100. PMID:31648038.
35.Lin X,WangY,WangL, LuY,Li J, Lu D, ZhouT,Huang Z, Huang J, Huang H,Qiu S, Chen R, Lin D, Feng S. Interference-free and high precision biosensor based on surface enhanced Raman spectroscopy integrated with surface molecularly imprinted polymer technology for tumor biomarker detection in human blood. Biosens Bioelectron. 2019 Oct 15;143:111599. doi: 10.1016/j.bios.2019.111599. Epub 2019 Aug 21. PMID:31476600.
36.Lin D , Gong T ,Qiu S,WuQ ,TsengCY , Kong KV , Chen G , Chen R . A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA. Chem Commun (Camb). 2019 Jan 31;55(11):1548-1551. doi: 10.1039/c8cc07461e. PMID: 30534756.
37.Guo Q, LuT,Hui Huang S, O'Sullivan B, Zong J, XiaoY,XuW,Chen C,Qiu S, Xu L, ZhengW,ChenY,Lin S, Pan J. Depicting distant metastatic risk by refined subgroups derived from the 8th edition nasopharyngeal carcinoma TNM. Oral Oncol. 2019 Apr;91:113-120. doi: 10.1016/j.oraloncology.2019.02.021. Epub 2019 Mar 12. PMID: 30926056.
38.Lin X,WangL, Lin H, Lin D, Lin J, Liu X,Qiu S, XuY,Chen G, Feng S.A novel urine analysis technique combining affinity chromatography with Au nanoparticle based surface enhancedRamanspectroscopyforpotentialapplicationsinnon-invasivecancerscreening.J Biophotonics.2019 Apr;1.12(4):e201800327. doi: 10.1002/jbio.201800327. PMID: 30447050.
