郭磊

作者: 时间:2023-11-22 点击数:

职称:副研究员,硕士生导师

研究方向:人工智能与影像处理、空间多组学数据分析

电子邮件:gankLei@fzu.edu.cn

个人简介:郭磊,男,博士毕业于厦门大学国家健康医疗大数据研究院。近五年以第一作者或通讯作者发表SCI期刊论文10余篇,参与多个国家或省级基金项目。

主要科研项目:

1.福州大学科研启动金(项目编号:511344),深度学习助力高分辨质谱成像数据的自动化分子鉴定,10(万),2023年-2025年,在研,主要负责人。

2.国家自然科学基金(项目编号:82372087),多尺度代谢互作网络分析新方法应用于阿尔兹海默病空间代谢组学研究,50(万),2024年-2027年,在研,主要参与人。

3.福建省科技厅科学基金项目(项目编号:2022Y0003),基于多尺度空间代谢组学的阿尔兹海默病早期诊断及分子机制研究,10(万),2022年-2025年,在研,主要参与人。

4.上海鹿明生物科技有限公司横向项目(项目编号:20223160A0364),原位质谱代谢物定性解析程序开发,18(万),2022年–2023年,结题,主要参与人。

近年发表的主要论文(时间排序):

1.Lei Guo,Chengyi Xie, Rui Miao, Jingjing Xu, Xiangnan Xu, Jiacheng Fang, Xiaoxiao Wang, Wuping Liu, Xiangwen Liao, Jianing Wang, Jiyang Dong, and Zongwei Cai. DeepION: A Deep Learning-Based Low-Dimensional Representation Model of Ion Images for Mass Spectrometry Imaging.Analytical Chemistry, 2024, 96(9): 3829–3836 (中科院1区, IF = 7.4).

2.Jiacheng Fang,Lei Guo*, Yanhao Zhang, Qing Guo, Ming Wang, Xiaoxiao Wang. The Target Atlas for Antibody-Drug Conjugates across Solid Cancers.Cancer Gene Therapy, 2024, 31(2), 273-284 (中科院3区,IF = 6.4).

3.Lei Guo, Jinyu Zhu, Keqi Wang, Kian-kai Cheng, Jingjing Xu, Liheng Dong, Xiangnan Xu, Can Chen, Mudassir Shah, Zhangxiao Peng, Jianing Wang, Zongwei Cai and Jiyang Dong. Multimodal Image Registration and Fusion to Improve Spatial Resolution of Mass Spectrometry Imaging.Analytical Chemistry, 2023, 95(25), 9714- 9721(中科院1区, IF = 7.4).

4.Xingxing Liu, Yifan Wu,Lei Guo, Xiaoyu Wang, Changkai Shan, Yaru Liu, Hanxiang An, Xinmei Kang, Rong Ding, Zongwei Cai, Jiyang Dong, Yufen Zhao, Xiang Gao. Comprehensive Profiling of Amine-Containing Metabolite Isomers with Chiral Phosphorus Reagents.Analytical Chemistry, 2023, 95(46), 16830-16839 (中科院1区, IF = 7.4).

5.Lei Guo, Jiyang Dong, Xiangnan Xu, Zhichao Wu, Yinbin Zhang, Yongwei Wang, Pengfei Li, Zhi Tang, Chao Zhao and Zongwei Cai. Divide-and-conquer: a flexible deep learning strategy for exploring metabolic heterogeneity from mass spectrometry imaging data.Analytical Chemistry, 2023, 95(3), 1923-1932 (中科院1区, IF = 7.4).

6.Qian Lu, Chunyang Ma,Lei Guo, Yujie Lu, Huankai Li. Co-Fermentation of Chlorella vulgaris with Oleaginous Yeast in Starch Processing Effluent as a Carbon-Reducing Strategy for Wastewater Treatment and Biofuel Feedstock Production.Fermentation, 2023, 9(5), 476 (中科院3区, IF = 4.5).

7.Lei Guo, Xingxing Liu, Chao Zhao, Zhenxing Hu, Xiangnan Xu, Kian-kai Cheng, Peng Zhou, Yu Xiao, Mudassir Shah, Jingjing Xu, Jiyang Dong and Zongwei Cai. iSegMSI: An Interactive Strategy to Improve Spatial Segmentation of Mass Spectrometry Imaging Data.Analytical Chemistry, 2022, 94(42), 14522–14529 (中科院1区, IF = 7.4).

8.Chao Zhao,Lei Guo, Jiyang Dong and Zongwei Cai. Mass spectrometry imaging-based multi-modal technique: The next-generation of biochemical analysis strategy.The Innovation, 2(4), 100151, 2021 (中科院1区, IF = 32.1).

9.Lei Guo, Zhenxing Hu, Chao Zhao, Xiangnan Xu, Shujuan Wang, Jingjing Xu, Jiyang Dong, Zongwei Cai. Data Filtering and Its Prioritization in Pipelines for Spatial Segmentation of Mass Spectrometry Imaging.Analytical Chemistry, 2021, 93(11), 4788-4793 (中科院1区, IF = 7.4).

10.Lei Guo, Yongpei Wang, Xiangnan Xu, Kian-kai Cheng, Yichi Long, Jingjing Xu, Sanshu Li and Jiyang Dong. DeepPSP: A Global–Local Information-Based Deep Neural Network for the Prediction of Protein Phosphorylation Sites.Journal of Proteome Research, 2020, 20(1), 346-356 (中科院2区, IF = 4.4).

11.Lei Guo, Shunfang Wang, Mingyuan Li and Zicheng Cao. Accurate classification of membrane protein types based on sequence and evolutionary information using deep learning.BMC Bioinformatics, 2019, 20(1), 25 (中科院3区, IF = 3).

12.郭磊王顺芳.序列信息融合与两阶段特征选择的膜蛋白预测.计算机工程与应用2019, 55(6), 145-150. (中文核心)

13.Lei Guo, Shunfang Wang, Zhenfeng Lei, Xueren Wang. Prediction for Membrane Protein Types Based on Effective Fusion Representation and MIC-GA Feature Selection.IEEE Access, 2018, 6, 75669-75681 (中科院3区, IF = 4.1).

发明专利:

1.董继扬,郭磊,胡振兴,徐向南,许晶晶.一种用于质谱成像数据的交互式空间分割方法,2022.05,公开;发明专利,公开号:CN 114494175A

2.董继扬,先后松,郭磊,朱晋宇.一种H&E染色显微图像驱动的质谱成像超分辨重构方法,2022.11.01,公开;发明专利,公开号:CN 115272069A

3.许晶晶,黄自鑫,郭磊,董继扬.用于预测蛋白质翻译后修饰位点的深度学习方法,2022.07.08,公开;发明专利,公开号:CN 114724630A

4.王顺芳,邓琳,房园,郭磊,曹子成.一种从生物医学文本中挖掘蛋白质亚细胞定位信息的方法,2021.08,授权;发明专利,专利号:ZL201810436260.1

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